DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and JAK1

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001307852.1	Gene:	JAK1 / 3716	HGNCID:	6190	Length:	1154	Species:	Homo sapiens

Alignment Length:	652	Identity:	161/652 - (24%)
Similarity:	262/652 - (40%)	Gaps:	152/652 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKCC------------SKRQDQELALAYPTGGYK-----KSDYTFGQ-------THINSSGGG 41
            |..:||            :.::.||....||.....     |.|...|:       |||.|
Human   539 MLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYS---- 599

  Fly    42 NMGGVLGQKHNNGGSLDSRY-----TPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVV 101
              |.::..|.:.|.|.:.:.     ..||:||           ||.........:...|..:.:|
Human   600 --GTLMDYKDDEGTSEEKKIKVILKVLDPSHR-----------DISLAFFEAASMMRQVSHKHIV 651

  Fly   102 ALYDYKSRDESDL---SFMKGDRMEVIDDTESD-----W-WRVV--------------------- 136
            .||....||..::   .|::|..:::....:||     | ::|.
Human   652 YLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVC 716

  Fly   137 --NLTTRQEGL--------------IPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGT 185
              ||...:||:              ||:..::.:..:....|.....:....:..:.|::...||
Human   717 TKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT 781

  Fly   186 FLVRPSEHNPNGYSLSVKD---WEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKE 247
            .|   .|...|| .:.:||   .|..|.|..:...:.|         :.:....|....|.|. .
Human   782 TL---WEICYNG-EIPLKDKTLIEKERFYESRCRPVTP---------SCKELADLMTRCMNYD-P 832

  Fly   248 NALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSE-----IQLLRKLGRGNFGEVFYGKWRNS 307
            |.......:.|...|.:.|..|:..|.:...|:..:.     ::.:|.||.|:||:|...::...
Human   833 NQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPE 897

  Fly   308 ID-----VAVKTLR--EGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE--EPIYIVQEYMSKG 363
            .|     ||||:|:  .|....|...:|..|::...|..:|....:|:::  ..|.::.|::..|
Human   898 GDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG 962

  Fly   364 SLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLAR 428
            ||.::|.:...: ::.:..:..|.|:..||:||.|:|.:||||||||||:...:..||.||||.:
Human   963 SLKEYLPKNKNK-INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTK 1026

  Fly   429 VIADDE--YCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTY-------------- 477
            .|..|:  |..|.....||.|.|||.::..||.|.|||||:|:.|.||.||
Human  1027 AIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKM 1091

  Fly   478 -----GQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYF 537
                 ||     |....::..::.|.|:|.|.|  .||.:|||:.:||:..|..|.:|:.|...|
Human  1092 IGPTHGQ-----MTVTRLVNTLKEGKRLPCPPN--CPDEVYQLMRKCWEFQPSNRTSFQNLIEGF 1149

  Fly   538 ES 539
            |:
Human  1150 EA 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	17/96 (18%)
		SH2_Src_family	158..259	CDD:199827	18/103 (17%)
		STYKc	285..537	CDD:214568	93/281 (33%)
		PTKc_Src_like	289..538	CDD:270630	93/278 (33%)
JAK1	NP_001307852.1	B41	37..286	CDD:214604
		FERM_C_JAK1	282..426	CDD:275412
		SH2	426..527	CDD:301589
		PTK_Jak1_rpt1	583..846	CDD:270662	52/293 (18%)
		Pkinase_Tyr	583..845	CDD:285015	52/292 (18%)
		PTKc_Jak1_rpt2	870..1153	CDD:173644	95/290 (33%)
		TyrKc	875..1149	CDD:197581	93/281 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810