DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and ITK

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_005537.3	Gene:	ITK / 3702	HGNCID:	6171	Length:	620	Species:	Homo sapiens

Alignment Length:	522	Identity:	188/522 - (36%)
Similarity:	274/522 - (52%)	Gaps:	54/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LGQKHNNGGSLDSRYTP------------------------DPNHRGPLKIGGKGGVDIIRPRTT 87
            |.::..|..||..:|.|                        ||......|.......|..||...
Human   106 LKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWE 170

  Fly    88 PTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVA 152
            |.       :.||:|||||::.|..:|:..:.:...::|.:|..||||.: ....||.:|.:::.
Human   171 PE-------ETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLV 227

  Fly   153 EERSVNSE--DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHV 213
            |:...|.|  :|:.:::.|.:|:|||| :....|.|:||.| .....|::||  |.........:
Human   228 EKSPNNLETYEWYNKSISRDKAEKLLL-DTGKEGAFMVRDS-RTAGTYTVSVFTKAVVSENNPCI 290

  Fly   214 KHYRIKPLDNG--GYYIATNQTFPSLQALVMAYSKENALGLCHILSRP-CPKPQPQMWDLGPELR 275
            |||.||..::.  .||:|....|.|: .|::.|.:.|..||...|..| |...|......|  ||
Human   291 KHYHIKETNDNPKRYYVAEKYVFDSI-PLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG--LR 352

  Fly   276 -DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNR 339
             .|:.|..||:..::::|.|.||.|..|.|.|...||:||:|||.||...|::||.:|.|..|.:
Human   353 YGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPK 417

  Fly   340 LVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHR 404
            ||.||.||.::.||.:|.|:|..|.|.|:||...|.:. .|.|:.:...|..||.|||...:|||
Human   418 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFA-AETLLGMCLDVCEGMAYLEEACVIHR 481

  Fly   405 DLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGI 469
            ||||||.|:|||.|.|:.|||:.|.:.||:|....|::|||||.:||...:.::|.||||||:|:
Human   482 DLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGV 546

  Fly   470 LLMELFTYGQVPYPGMHSREVIENIERGFRMPKP---TNHYFPDNIYQLLLQCWDAVPEKRPTFE 531
            |:.|:|:.|::||....:.||:|:|..|||:.||   :.|     :||::..||...||.||.|.
Human   547 LMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTH-----VYQIMNHCWKERPEDRPAFS 606

  Fly   532 FL 533
            .|
Human   607 RL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	18/50 (36%)
		SH2_Src_family	158..259	CDD:199827	34/106 (32%)
		STYKc	285..537	CDD:214568	112/252 (44%)
		PTKc_Src_like	289..538	CDD:270630	112/248 (45%)
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944	6/41 (15%)
		SH3_ITK	174..229	CDD:212841	18/55 (33%)
		SH2_Tec_Itk	232..340	CDD:198259	35/110 (32%)
		PTKc_Itk	358..613	CDD:133243	115/257 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810