DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Bmx

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001102486.1	Gene:	Bmx / 367786	RGDID:	1565643	Length:	655	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	183/534 - (34%)
Similarity:	267/534 - (50%)	Gaps:	86/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DPNHRGP------LKIGGKGGVDIIRPRTTPTGVPGVVLK------RVVVALYD------YKSRD 110
            |..||.|      |||          ||..|      :||      ..:...||      |.|:.
  Rat   162 DEKHRAPTFPERILKI----------PRAVP------ILKMDASSSSAIPPQYDSHLKKSYDSQP 210

  Fly   111 ESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQE----GLIPLNFVA-----------------EE 154
            ..::.::..:..       .|||::....:.::    ..:..|.|:                 ||
  Rat   211 TVNIRYIPREDC-------PDWWQIRKPKSEEDIARSNQLERNIVSHSPSKMSWGFPESSSSEEE 268

  Fly   155 RSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHVKHYR 217
            .::::.|||..|:.|.:::: ||.::...|.|:||.|. ....|::|:  |...|.:| .||||.
  Rat   269 ENLDAYDWFAGNISRSQSEQ-LLRQKGKEGAFMVRNSS-QMGMYTVSLFSKAVNDKKG-TVKHYH 330

  Fly   218 IKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPC---PKPQPQMWDLGPELRDKYE 279
            :........|:|.|..|.|:..|: .|.:.|:.|:...|..|.   ....|....||..:   :|
  Rat   331 VHTNAENKLYLAENYCFDSIPKLI-HYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGI---WE 391

  Fly   280 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALY 344
            :.|.||.||::||.|.||.|..|||:....||||.::||.||...|.|||..|.|..|.:||..|
  Rat   392 LKREEIALLKELGSGQFGVVQLGKWKGQYSVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFY 456

  Fly   345 AVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAAR 409
            .|||::.|||||.||::.|.||::|: ..|:.|....|:.:...|..||.:|||.|.||||||||
  Rat   457 GVCSKKYPIYIVTEYITNGCLLNYLK-NHGKGLESSQLLEMCYDVCEGMAFLESHQFIHRDLAAR 520

  Fly   410 NVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMEL 474
            |.|:..:...|:.|||:.|.:.||:|....|::|||||:|||...|.|:|.|||||::|||:.|:
  Rat   521 NCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEV 585

  Fly   475 FTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFES 539
            |:.|:.||....:.||:..:.:|.|:.:|  ....|.|||::..||..:|||||||:.|....|
  Rat   586 FSLGKQPYDLYDNSEVVVKVSQGHRLYRP--QLASDTIYQIMYSCWHELPEKRPTFQQLLSAIE- 647

  Fly   540 FSVTSEVPYREVQD 553
                   |.|| ||
  Rat   648 -------PLRE-QD 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	7/60 (12%)
		SH2_Src_family	158..259	CDD:199827	31/102 (30%)
		STYKc	285..537	CDD:214568	116/251 (46%)
		PTKc_Src_like	289..538	CDD:270630	113/248 (46%)
Bmx	NP_001102486.1	PH_Btk	25..151	CDD:269944
		PH	27..115	CDD:278594
		SH2_Tec_Bmx	269..374	CDD:198262	32/108 (30%)
		PKc_like	392..647	CDD:304357	118/257 (46%)
		Pkinase_Tyr	397..646	CDD:285015	116/251 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810