Protein Alignment Src64B and Ptk6

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001102438.1
• Gene: Ptk6 / 366275
• RGDID: 1309098
• Length: 451
• Species: Rattus norvegicus
• Alignment Length: 441
• Identity: 193/441 - (43%)
• Similarity: 260/441 - (58%)
• Gaps: 25/441 - (5%)

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVV---NLTTRQEGLIPLNFVAEERSVNSEDW 162
            |.|:|:|:|.:.:|||..||.:.|....|..||..:   ......||.:|.|::||:.:|.||.|
  Rat    14 VGLWDFKARTDEELSFQAGDLLHVTRKEEQWWWATLLDAEGKALAEGYVPHNYLAEKETVESEPW 78

  Fly   163 FFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYY 227
            ||..:.|.||...|.:|:.|:||||:|.|:.....|.|||.|.|     .|:||||.....|..:
  Rat    79 FFGCISRSEAMHRLQSEDYPKGTFLIRVSQKPGADYVLSVWDAE-----AVRHYRIWRNSAGRLH 138

  Fly   228 IATNQTFPSLQALVMAYSKENALGLCHILSRPCPK----PQPQMWDLGPELRDKYEIPRSEIQLL 288
            :....:|.||..|| .|.|.:.|.....||..|.|    |.|. |       |.:|.||.|..|.
  Rat   139 LNEVVSFSSLSELV-NYHKTHNLSPGLQLSMACWKLKTEPLPH-W-------DDWERPREEFTLC 194

  Fly   289 RKLGRGNFGEVFYGKWRNSIDVAVKTL-REGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEP 352
            :|||.|.|||||.|.|:..:.||||.: |:..:....|..|...|||.||..:::||||.:..:|
  Rat   195 KKLGSGYFGEVFEGLWKGLVRVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDP 259

  Fly   353 IYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENN 417
            :||:.|.|.|||||..||:.|.:.|...:|:..|:|||.||.||||:..|||||||||||:.|||
  Rat   260 VYIITELMPKGSLLQLLRDSDEKDLPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENN 324

  Fly   418 VAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPY 482
            :.|:.||||||::.:|.|..:. ...|.|||||||:..|.:||||||||:|:||.|:|:.||:||
  Rat   325 LCKVGDFGLARLVKEDIYLSRD-HNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPY 388

  Fly   483 PGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            |||.:.|....::.|:|||.|..  .|.||::|:|.||...|::||.|:.|
  Rat   389 PGMSNHETFLRVDAGYRMPCPLE--CPPNIHKLMLSCWSRDPKQRPCFKDL 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	39/100 (39%)
		PTKc_Src_like	289..538	CDD:270630	122/246 (50%)
		SH3_Src_like	99..150	CDD:212779	17/51 (33%)
Ptk6	NP_001102438.1	SH3_Brk	12..69	CDD:212781	18/54 (33%)
		SH2_PTK6_Brk	75..174	CDD:198221	41/104 (39%)
		Protein Kinases, catalytic domain	184..444	CDD:473864	127/257 (49%)