DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Ptk6

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001102438.1	Gene:	Ptk6 / 366275	RGDID:	1309098	Length:	451	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	193/441 - (43%)
Similarity:	260/441 - (58%)	Gaps:	25/441 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVV---NLTTRQEGLIPLNFVAEERSVNSEDW 162
            |.|:|:|:|.:.:|||..||.:.|....|..||..:   ......||.:|.|::||:.:|.||.|
  Rat    14 VGLWDFKARTDEELSFQAGDLLHVTRKEEQWWWATLLDAEGKALAEGYVPHNYLAEKETVESEPW 78

  Fly   163 FFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYY 227
            ||..:.|.||...|.:|:.|:||||:|.|:.....|.|||.|.|     .|:||||.....|..:
  Rat    79 FFGCISRSEAMHRLQSEDYPKGTFLIRVSQKPGADYVLSVWDAE-----AVRHYRIWRNSAGRLH 138

  Fly   228 IATNQTFPSLQALVMAYSKENALGLCHILSRPCPK----PQPQMWDLGPELRDKYEIPRSEIQLL 288
            :....:|.||..|| .|.|.:.|.....||..|.|    |.|. |       |.:|.||.|..|.
  Rat   139 LNEVVSFSSLSELV-NYHKTHNLSPGLQLSMACWKLKTEPLPH-W-------DDWERPREEFTLC 194

  Fly   289 RKLGRGNFGEVFYGKWRNSIDVAVKTL-REGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEP 352
            :|||.|.|||||.|.|:..:.||||.: |:..:....|..|...|||.||..:::||||.:..:|
  Rat   195 KKLGSGYFGEVFEGLWKGLVRVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDP 259

  Fly   353 IYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENN 417
            :||:.|.|.|||||..||:.|.:.|...:|:..|:|||.||.||||:..|||||||||||:.|||
  Rat   260 VYIITELMPKGSLLQLLRDSDEKDLPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENN 324

  Fly   418 VAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPY 482
            :.|:.||||||::.:|.|..:. ...|.|||||||:..|.:||||||||:|:||.|:|:.||:||
  Rat   325 LCKVGDFGLARLVKEDIYLSRD-HNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPY 388

  Fly   483 PGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            |||.:.|....::.|:|||.|..  .|.||::|:|.||...|::||.|:.|
  Rat   389 PGMSNHETFLRVDAGYRMPCPLE--CPPNIHKLMLSCWSRDPKQRPCFKDL 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	17/51 (33%)
		SH2_Src_family	158..259	CDD:199827	39/100 (39%)
		STYKc	285..537	CDD:214568	123/250 (49%)
		PTKc_Src_like	289..538	CDD:270630	122/246 (50%)
Ptk6	NP_001102438.1	SH3_Brk	12..69	CDD:212781	18/54 (33%)
		SH2_PTK6_Brk	75..174	CDD:198221	41/104 (39%)
		PKc_like	184..444	CDD:304357	127/257 (49%)
		STYKc	192..441	CDD:214568	123/249 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820