DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Ack-like

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	131/416 - (31%)
Similarity:	191/416 - (45%)	Gaps:	52/416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 TESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSE 192
            |||:..:..|....:   :.:...|:.:....||..|..:.|.|..:|....|           :
  Fly    13 TESELQQYYNAVKNE---LKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYE-----------K 63

  Fly   193 HNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILS 257
            |.|:.|...:|......|..||.   :....||..:|.:.:  |..|.....:|..|       |
  Fly    64 HFPHSYLSKIKRLLQAPGTMVKR---EEAPGGGSQVALDGS--SASACSSLAAKNGA-------S 116

  Fly   258 RPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNS---IDVAVKTL-REG 318
            .|...|           .:|:.||...|.:.::||.|.||.|..|.|.|.   |.||:|.| ||.
  Fly   117 SPSKVP-----------NNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRER 170

  Fly   319 TMST-AAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGR--YLHFE 380
            ..|. ..||:|||||....|..:|.||.|....:.:.:|.|.....|||:.|::...|  :|...
  Fly   171 MQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIP 235

  Fly   381 DLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARV--IADDEYCP--KQGS 441
            .|...|.|:.:||.|||.|:||||||||||:|:...:..||.||||:|.  :..|.|..  ....
  Fly   236 TLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNL 300

  Fly   442 RFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIE--RGFRMPKPT 504
            :.|:.|.|||.|.|.:|:..||||::|:.|.|:|:||..|:..:...:::|.|:  ...|:.:|
  Fly   301 KLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQP- 364

  Fly   505 NHYFPDNIYQLLLQCWDAVPEKRPTF 530
             ...|...|.|:::||.....|||.|
  Fly   365 -DCCPSEYYTLMMKCWQDDAAKRPRF 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	4/21 (19%)
		SH2_Src_family	158..259	CDD:199827	22/100 (22%)
		STYKc	285..537	CDD:214568	99/259 (38%)
		PTKc_Src_like	289..538	CDD:270630	98/255 (38%)
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	12/65 (18%)
		STYKc	133..396	CDD:214568	99/259 (38%)
		PTKc_Ack_like	137..398	CDD:270636	98/255 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950