DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and Itk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001102295.2	Gene:	Itk / 363577	RGDID:	1311618	Length:	620	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	178/480 - (37%)
Similarity:	263/480 - (54%)	Gaps:	39/480 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVID 126
            ||:.|.|           ....|..|           :|:|||||::.|..:|:..:.:...::|
  Rat   160 TPEDNRR-----------SFQEPEET-----------LVIALYDYQTNDPQELALRRDEEYYLLD 202

  Fly   127 DTESDWWRVVNLTTRQEGLIPLNFVAEE--RSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVR 189
            .:|..||||.: ....||..|.:::.|:  .|:.:.:|:.:::.|.:|:|||| :....|.|:||
  Rat   203 SSEIHWWRVQD-KNGHEGYAPSSYLVEKSPNSLETYEWYNKSISRDKAEKLLL-DTGKEGAFMVR 265

  Fly   190 PSEHNPNGYSLSV--KDWEDGRGYHVKHYRIKPLDNG--GYYIATNQTFPSLQALVMAYSKENAL 250
            .| ..|..|::||  |.........:|||.||..::.  .||:|....|.|:..|:. |.:.|..
  Rat   266 DS-RTPGTYTVSVFTKAIISENNPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQ-YHQYNGG 328

  Fly   251 GLCHILSRP-CPKPQPQMWDLGPELR-DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVK 313
            ||...|..| |...|......|  || .|:.|..||:..::::|.|.||.|..|.|.|...||:|
  Rat   329 GLVTRLRYPVCSWRQKAPVTAG--LRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIK 391

  Fly   314 TLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLH 378
            |::||.||...|::||.:|.|..|.:||.||.||.::.||.:|.|:|..|.|.|:||...|.:.
  Rat   392 TIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFA- 455

  Fly   379 FEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRF 443
            .|.|:.:...|..||.|||...:|||||||||.|:|||.|.|:.|||:.|.:.||:|....|::|
  Rat   456 AETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKF 520

  Fly   444 PVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF 508
            ||||.:||...:.::|.||||||:|:|:.|:|:.|::||....:.||:|:|..|||:.||  ...
  Rat   521 PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKP--RLA 583

  Fly   509 PDNIYQLLLQCWDAVPEKRPTFEFL 533
            ..::||::..||...||.||.|..|
  Rat   584 SPHVYQVMNHCWKEKPEDRPPFSRL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	17/50 (34%)
		SH2_Src_family	158..259	CDD:199827	33/104 (32%)
		STYKc	285..537	CDD:214568	110/249 (44%)
		PTKc_Src_like	289..538	CDD:270630	110/245 (45%)
Itk	NP_001102295.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810