DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and yrk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001352482.1	Gene:	yrk / 337571	ZFINID:	ZDB-GENE-030131-9517	Length:	528	Species:	Danio rerio

Alignment Length:	561	Identity:	266/561 - (47%)
Similarity:	357/561 - (63%)	Gaps:	50/561 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKCCSKRQDQELALAYPTGGYKKSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLDSRYTPDP 65
            ||..||.:|              |.|.....|...::..|            ...|..|||.|||
Zfish     1 MGCACCKQR--------------KASKAVSNQNSCDAFNG------------TQASEPSRYIPDP 39

  Fly    66 NHRGPLKIGGKGGV----DIIRPRTTPTGV------PGVVLKRVV--VALYDYKSRDESDLSFMK 118
            ..        ..|:    |...|.|.||.:      ||:....|.  :|||:|.:|.|.||||.|
Zfish    40 TF--------NSGIPNFNDFSNPLTPPTSIINPARPPGLTGGGVTLFIALYEYDARTEDDLSFQK 96

  Fly   119 GDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPR 183
            |::..:|::||.|||...:|.|.:.|.||.|:||...|:.:|:|:|..:.||:|::.|||:.|||
Zfish    97 GEKFHIINNTEGDWWEARSLDTGKSGYIPSNYVAPVDSIQAEEWYFGKMGRKDAERQLLAQNNPR 161

  Fly   184 GTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKEN 248
            ||||:|.||.....||||::||:|.:|.|||||:|:.||||||||.|...|.::|.||..|: |.
Zfish   162 GTFLIRESETTKGAYSLSIRDWDDAKGDHVKHYKIRKLDNGGYYITTRTQFDTVQQLVEHYT-ER 225

  Fly   249 ALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVK 313
            |.|||..|...|.:..|::.||..:.:|.:||||..:||::|||.|.||||:.|.|..:..||||
Zfish   226 AAGLCCRLIGSCRRGMPKLADLSVKTKDVWEIPRESLQLIKKLGNGQFGEVWMGMWNGTTKVAVK 290

  Fly   314 TLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLH 378
            ||:.||||..|||.||.|||:.||::||.||||.| ||||||:.|:||:|||||||::||||.|.
Zfish   291 TLKPGTMSPEAFLDEAQIMKRLRHDKLVQLYAVVS-EEPIYIITEFMSQGSLLDFLKDGDGRNLK 354

  Fly   379 FEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRF 443
            ...|:.:|.|:|:||.|:|....|||||.|.|:|:|:..|.||.||||||:|.|:||..:||::|
Zfish   355 LPQLVDMAAQIAAGMAYIERMNYIHRDLRAANILVGDGLVCKIADFGLARLIEDNEYTARQGAKF 419

  Fly   444 PVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF 508
            |:|||||||.:||||:|||||||:||||.||.|.|:||||||::|||:|.:|||:|||.|...
Zfish   420 PIKWTAPEAALYGKFTIKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVERGYRMPCPQGS-- 482

  Fly   509 PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            |.::::|:||||...|::|.|||:|..:.|.:...:|..|:
Zfish   483 PASLHELMLQCWRKDPDERHTFEYLQSFLEDYFTATEPQYQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	24/52 (46%)
		SH2_Src_family	158..259	CDD:199827	53/100 (53%)
		STYKc	285..537	CDD:214568	149/251 (59%)
		PTKc_Src_like	289..538	CDD:270630	147/248 (59%)
yrk	NP_001352482.1	SH3	76..133	CDD:327375	26/56 (46%)
		SH2	136..234	CDD:326550	52/98 (53%)
		PTKc_Src_Fyn_like	266..513	CDD:271105	147/249 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920