DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and src

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_017209008.1	Gene:	src / 325084	ZFINID:	ZDB-GENE-030131-3809	Length:	549	Species:	Danio rerio

Alignment Length:	556	Identity:	262/556 - (47%)
Similarity:	357/556 - (64%)	Gaps:	61/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 MGGV------LGQKHNNGGSLDS------RYTPDPN----HRGPLKIGGKGGV--DIIRPR---- 85
            ||||      |||:..   |||.      .:||:|.    :|.|...|.:.|.  :||...
Zfish     1 MGGVKSKPKELGQRSR---SLDDGTGGHHHHTPNPTSFTPNRSPPVEGSRRGTQPNIINAEQALF 62

  Fly    86 ----------TTPT--GVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDT------ESDW 132
                      |:|.  |:.|.|  ...||||||:||..|||||.||:|::::::|      |.||
Zfish    63 GGVNSTTNSITSPNRIGILGGV--TTFVALYDYESRTASDLSFRKGERLQIVNNTRKLNPREGDW 125

  Fly   133 WRVVNLTTRQEGLIPLNFVAEERSVNSED---------WFFENVLRKEADKLLLAEENPRGTFLV 188
            |...:|||.:.|.||.|:||...|:.:||         |:|..:.|:::::|||..||.||||||
Zfish   126 WLARSLTTGESGYIPSNYVAPSDSIQAEDHLRLTLEKRWYFGKITRRDSERLLLNLENRRGTFLV 190

  Fly   189 RPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLC 253
            |.||.....|.|||.|:::.:|.:||||:|:.||:||:||.:...|.:||.||..| :::|.|||
Zfish   191 RESETTKGAYCLSVLDYDNVKGLNVKHYKIRKLDSGGFYITSRTQFSTLQQLVNHY-RQHADGLC 254

  Fly   254 HILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREG 318
            |.|:..||..:|....|.   ||.:||||..::|..|||:|.||||:.|.|..:..||:|||:.|
Zfish   255 HSLTDVCPVLKPPTQGLA---RDAWEIPRDSLRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG 316

  Fly   319 TMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLI 383
            |||..||||||.:|||.||.:||.||||.| |||||||.|||.:|||||||:...|:.|....|:
Zfish   317 TMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMGQGSLLDFLKGDMGKMLRLPQLV 380

  Fly   384 YIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWT 448
            .:|:|:||||.|:|....:||||.|.|:|:|:|.|.|:.||||||:|.|:||..:||::||:|||
Zfish   381 DMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 445

  Fly   449 APEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIY 513
            ||||.:||:|:|||||||:||||.||.|.|:||||||.:|||::.:|||:|||.|..  .||:::
Zfish   446 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPAE--CPDSLH 508

  Fly   514 QLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            :|:|.||...||:|||||:|..:.|.:..::|..|:
Zfish   509 ELMLTCWRKEPEERPTFEYLQGFLEDYFTSTEPQYQ 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	27/56 (48%)
		SH2_Src_family	158..259	CDD:199827	48/109 (44%)
		STYKc	285..537	CDD:214568	146/251 (58%)
		PTKc_Src_like	289..538	CDD:270630	145/248 (58%)
src	XP_017209008.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21120
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.880