DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and Wsck

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_733018.1	Gene:	Wsck / 318600	FlyBaseID:	FBgn0046685	Length:	791	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	128/552 - (23%)
Similarity:	208/552 - (37%)	Gaps:	151/552 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 TTPTGVPGVVLKRVVVALYDYKSRDES----DLSFMKGDR---------MEVIDDTES------- 130
            ||..|:|..|..:..:.     ||.:.    :||.::.|.         :|.:|:..|
  Fly   242 TTEVGLPSPVPAQPKIL-----SRTDRTVTIELSPIRNDNGPLSKLLVIVEYVDNALSQPFDAQL 301

  Fly   131 --DWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEH 193
              .|.:     .:|:| :|....||......||        ....:.::.:....|.|..:|.:
  Fly   302 LGSWQQ-----AQQDG-VPYYIAAELDYDRPED--------NRTRRFVVGDGKRYGRFTNKPLD- 351

  Fly   194 NPNGY---SLSVKDWEDG-------RGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKEN 248
            .|:.:   ||.:....:|       ||.|.:|  :..||:..|     .||...|:.|:|.:...
  Fly   352 QPDAHVHISLGLVSTLEGVTKTMYSRGTHDQH--VTSLDDFSY-----ATFEKGQSSVVALAVTC 409

  Fly   249 AL-GLCHILS---------RPC------------------------------PKPQPQMWDLGPE 273
            .: |.|.:||         :.|                              ..|.|.    .||
  Fly   410 VIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIERENNGYLVEDDPLPH----SPE 470

  Fly   274 --------LRDKYE-IPRSEIQLLRK--LGRGNFGEVFYGKWRNSIDVAVKTLR-------EGTM 320
                    |.:.|| |||:.::|...  :|.|.|||:..||...:......||.       .||
  Fly   471 NFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFARDCTLHVLCLDDLNGT- 534

  Fly   321 STAAFLQEAAIMKKF-RHNRLVALYAVCSQEEPIYIV--QEYMS-KGSLLDF-LREGDGRYLHFE 380
            :.|..|:|...:.:. |...|:..|.|.:..:..|::  |:.|| |..|::. |.....|.....
  Fly   535 TQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMSLKRKLVESRLMAPSPRLTSLS 599

  Fly   381 DLIYI--ATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFG------LARVIADDEYCP 437
            :.:.:  ..::||.|.||.|.|::||.|.:.:|.:..:...|:..||      :||...|..
  Fly   600 EQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSDFKLKLSVFGPLPYMNIARQQPDHN--- 661

  Fly   438 KQGSRFPVKWTAPEAIIY-GKFSIKSDVWSYGILLMELFTYGQVPYPG--MHSREVIENIERGFR 499
                    :|.|||.:.: ...|.:|||||...:..|....|..||..  ..:::::|.|....|
  Fly   662 --------RWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGTPYANAVASNQQLLEAIRAAVR 718

  Fly   500 MPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFE 531
            ..:|.  |...::|||||.||...|.:|.:.|
  Fly   719 PAQPA--YVYGDLYQLLLNCWQLEPSERSSCE 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	12/72 (17%)
		SH2_Src_family	158..259	CDD:199827	25/120 (21%)
		STYKc	285..537	CDD:214568	73/272 (27%)
		PTKc_Src_like	289..538	CDD:270630	72/268 (27%)
Wsck	NP_733018.1	WSC	42..115	CDD:280068
		fn3	130..222	CDD:278470
		TyrKc	493..746	CDD:197581	72/266 (27%)
		PTKc	497..750	CDD:270623	72/266 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010