DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Lck

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_006238994.1	Gene:	Lck / 313050	RGDID:	2994	Length:	520	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	228/498 - (45%)
Similarity:	328/498 - (65%)	Gaps:	26/498 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTG--VPGVVLK-RVVVALYDYKSRDESDLSFMK 118
            |||:.|.      |::.|.    ::..|..|..|  .|...|: .:|:||:.|:...:.||.|.|
  Rat    41 LDSKSTL------PIRTGS----EVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEK 95

  Fly   119 GDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPR 183
            |:::.:::.: .:||:..:|||.|||.||.||||:..|:..|.|||:|:.||:|::.|||..|..
  Rat    96 GEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTH 159

  Fly   184 GTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKEN 248
            |:||:|.||.....:||||:|::..:|..||||:|:.|||||:||:...|||.|..||..|:..:
  Rat   160 GSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNAS 224

  Fly   249 ALGLCHILSRPC--PKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVA 311
            . |||..|||||  .|||...|:      |::|:||..::|:.:||.|.||||:.|.:.....||
  Rat   225 D-GLCTKLSRPCQTQKPQKPWWE------DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVA 282

  Fly   312 VKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRY 376
            ||:|::|:||..|||.||.:||:.:|.|||.||||.:| |||||:.|||..|||:|||:...|..
  Rat   283 VKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIK 346

  Fly   377 LHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGS 441
            |:...|:.:|.|:|.||.::|.:..|||||.|.|:|:.:....||.||||||:|.|:||..::|:
  Rat   347 LNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 411

  Fly   442 RFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNH 506
            :||:||||||||.||.|:|||||||:||||.|:.|:|::|||||.:.|||:|:|:|:||.:|.|
  Rat   412 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLEKGYRMVRPDN- 475

  Fly   507 YFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
             .|:.:|.|::.||...||.||||::|....:.|...:|..|:
  Rat   476 -CPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	19/50 (38%)
		SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		STYKc	285..537	CDD:214568	131/251 (52%)
		PTKc_Src_like	289..538	CDD:270630	130/248 (52%)
Lck	XP_006238994.1	SH3_Lck	76..129	CDD:212938	22/53 (42%)
		SH2_Src_Lck	134..234	CDD:198225	48/100 (48%)
		PTKc_Lck_Blk	248..511	CDD:270652	135/265 (51%)
		Pkinase_Tyr	256..505	CDD:285015	131/251 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6609
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820