Protein Alignment Src64B and Lck

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_006238994.1
• Gene: Lck / 313050
• RGDID: 2994
• Length: 520
• Species: Rattus norvegicus
• Alignment Length: 498
• Identity: 228/498 - (45%)
• Similarity: 328/498 - (65%)
• Gaps: 26/498 - (5%)

  Fly    57 LDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTG--VPGVVLK-RVVVALYDYKSRDESDLSFMK 118
            |||:.|.      |::.|.    ::..|..|..|  .|...|: .:|:||:.|:...:.||.|.|
  Rat    41 LDSKSTL------PIRTGS----EVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEK 95

  Fly   119 GDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPR 183
            |:::.:::.: .:||:..:|||.|||.||.||||:..|:..|.|||:|:.||:|::.|||..|..
  Rat    96 GEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTH 159

  Fly   184 GTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKEN 248
            |:||:|.||.....:||||:|::..:|..||||:|:.|||||:||:...|||.|..||..|:..:
  Rat   160 GSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNAS 224

  Fly   249 ALGLCHILSRPC--PKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVA 311
            . |||..|||||  .|||...|:      |::|:||..::|:.:||.|.||||:.|.:.....||
  Rat   225 D-GLCTKLSRPCQTQKPQKPWWE------DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVA 282

  Fly   312 VKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRY 376
            ||:|::|:||..|||.||.:||:.:|.|||.||||.:| |||||:.|||..|||:|||:...|..
  Rat   283 VKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIK 346

  Fly   377 LHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGS 441
            |:...|:.:|.|:|.||.::|.:..|||||.|.|:|:.:....||.||||||:|.|:||..::|:
  Rat   347 LNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGA 411

  Fly   442 RFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNH 506
            :||:||||||||.||.|:|||||||:||||.|:.|:|::|||||.:.|||:|:|:|:||.:|.|
  Rat   412 KFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLEKGYRMVRPDN- 475

  Fly   507 YFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
             .|:.:|.|::.||...||.||||::|....:.|...:|..|:
  Rat   476 -CPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQ 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		PTKc_Src_like	289..538	CDD:270630	130/248 (52%)
		SH3_Src_like	99..150	CDD:212779	19/50 (38%)
Lck	XP_006238994.1	SH3_Lck	76..129	CDD:212938	22/53 (42%)
		SH2_Src_Lck	134..234	CDD:198225	48/100 (48%)
		PTKc_Lck_Blk	248..511	CDD:270652	135/265 (51%)