Protein Alignment Src64B and HCK

DIOPT Version :9

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_002101.2
• Gene: HCK / 3055
• HGNCID: 4840
• Length: 526
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 243/555 - (43%)
• Similarity: 348/555 - (62%)
• Gaps: 58/555 - (10%)

  Fly    10 QDQELALAYPTGGYKKSDY------TFGQTHINSSGGGNMGGVLGQKHNNGGSLDSRYTPDPNHR 68
            :|:|.|   |..|..||.:      ||.:|..::|....:                 |.|||.
Human    14 RDEERA---PRMGCMKSKFLQVGGNTFSKTETSASPHCPV-----------------YVPDPT-- 56

  Fly    69 GPLKIGGKGGVDIIRPRTTPTGVPGVVLKR-------VVVALYDYKSRDESDLSFMKGDRMEVID 126
            ..:|.|         |.:..:..||:   |       :|||||||::....||||.|||:|.|::
Human    57 STIKPG---------PNSHNSNTPGI---REAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLE 109

  Fly   127 DTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPS 191
            :: .:||:..:|.||:||.||.|:||...|:.:|:|||:.:.||:|::.|||..|..|:|::|.|
Human   110 ES-GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDS 173

  Fly   192 EHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHIL 256
            |.....|||||:|::..:|..||||:|:.|||||:||:...||.:||.||..|.|.|. |||..|
Human   174 ETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGND-GLCQKL 237

  Fly   257 SRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTM 320
            |.||...:||. |:     :|.:||||..::|.:|||.|.||||:...:.....|||||::.|:|
Human   238 SVPCMSSKPQKPWE-----KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSM 297

  Fly   321 STAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYI 385
            |..|||.||.:||..:|::||.|:||.: :|||||:.|:|:||||||||:..:|.......||..
Human   298 SVEAFLAEANVMKTLQHDKLVKLHAVVT-KEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF 361

  Fly   386 ATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAP 450
            :.|:|.||.::|.:..|||||.|.|:|:..:.|.||.||||||||.|:||..::|::||:|||||
Human   362 SAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 426

  Fly   451 EAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQL 515
            |||.:|.|:|||||||:||||||:.|||::|||||.:.|||..:|||:|||:|.|  .|:.:|.:
Human   427 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN--CPEELYNI 489

  Fly   516 LLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
            :::||...||:|||||::....:.|...:|..|::
Human   490 MMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQ 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	25/50 (50%)
		SH2_Src_family	158..259	CDD:199827	49/100 (49%)
		STYKc	285..537	CDD:214568	131/251 (52%)
		PTKc_Src_like	289..538	CDD:270630	130/248 (52%)
HCK	NP_002101.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		3/8 (38%)
		SH3	82..137	CDD:302595	28/55 (51%)
		SH2_Src_HCK	140..243	CDD:198226	51/103 (50%)
		PKc_like	254..524	CDD:304357	138/272 (51%)
		Pkinase_Tyr	262..511	CDD:285015	131/251 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920