DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Abl2

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_038946666.1	Gene:	Abl2 / 304883	RGDID:	1590898	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	192/474 - (40%)
Similarity:	277/474 - (58%)	Gaps:	38/474 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFE 165
            |||||:.:..::.||..||:::.|:...::..|..|. :...:|.:|.|::....|:....|:..
  Rat   113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKHSWYHG 176

  Fly   166 NVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIAT 230
            .|.|..|:.||.:..|  |:||||.||.:|...|:|::  .:||.|   ||||....:...|:..
  Rat   177 PVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR--YEGRVY---HYRINTTTDSKVYVTA 234

  Fly   231 NQTFPSLQALVMAYSKENALGLCHILSRPCPK-PQPQMWDLGPELRDKYEIPRSEIQLLRKLGRG 294
            ...|.:|..||..:|.. |.||...|..|.|| .:|.::.:.| :.||:|:.|::|.:..|||.|
  Rat   235 ESRFSTLAELVHHHSTV-ADGLVTTLHYPAPKCNKPTVYGVSP-IHDKWEMERTDITMKHKLGGG 297

  Fly   295 NFGEVFYGKWRN-SIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQE 358
            .:|||:.|.|:. |:.||||||:|.||....||:|||:||:.:|..||.|..||:.|.|.|||.|
  Rat   298 QYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 362

  Fly   359 YMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICD 423
            ||..|:|||:|||.....:....|:|:|||::|.|||||.|..|||||||||.|:|||:|.|:.|
  Rat   363 YMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 427

  Fly   424 FGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSR 488
            |||:|::..|.|....|::||:||||||::.|..||||||||::|:||.|:.|||..||||:...
  Rat   428 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 492

  Fly   489 EVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESF------------- 540
            :|.:.:|:|:||.:|..  .|..:|:|:..||...|..||:|...:..||:.
  Rat   493 QVYDLLEKGYRMEQPEG--CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEDFVFF 555

  Fly   541 -----------SVTSEVPY 548
                       |.:|.|||
  Rat   556 TEVAEELGRTASSSSVVPY 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/48 (29%)
		SH2_Src_family	158..259	CDD:199827	34/100 (34%)
		STYKc	285..537	CDD:214568	126/252 (50%)
		PTKc_Src_like	289..538	CDD:270630	125/249 (50%)
Abl2	XP_038946666.1	SH3_Abl	111..164	CDD:212784	15/51 (29%)
		SH2_ABL	169..262	CDD:198189	34/100 (34%)
		PTKc_Abl	281..543	CDD:270645	130/263 (49%)
		FABD	1069..1188	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910