Protein Alignment Src64B and jak1

DIOPT Version :9

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_571148.1
• Gene: jak1 / 30280
• ZFINID: ZDB-GENE-980526-142
• Length: 1153
• Species: Danio rerio
• Alignment Length: 528
• Identity: 141/528 - (26%)
• Similarity: 232/528 - (43%)
• Gaps: 110/528 - (20%)

  Fly    69 GPLKIGGKGGVDIIRPRTTP--TGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESD 131
            |||.:       .:|.:|||  |.....|.|::.           |.||:::..:|      ...
Zfish   672 GPLDL-------FMRRQTTPLSTAWKFQVAKQLA-----------SALSYLEDKKM------VHG 712

  Fly   132 WWRVVNLTTRQEGL--------------IPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENP 182
            :....|:...::||              ||:..::.|..|:...|.....::..|:..:.|::..
Zfish   713 YVCSKNILVARDGLDGEGGPFIKLSDPGIPITVLSREECVDRIPWIAPECVKDTANLSIAADKWS 777

  Fly   183 RGTFLVRPSEHNPNGYSLSVKD---WEDGRGYHVKHYRIKP-LDNGGYYIATNQTFPSLQAL--- 240
            .||.|   .|...|| .:.:||   .|..|.|..:.....| .|.....:....|:...|.|
Zfish   778 FGTTL---WEICYNG-EIPLKDKKLTEKERFYAAQCQLATPDCDELAKLMTHCMTYDPRQRLFFR 838

  Fly   241 -----VMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVF 300
                 ::...|:|          |..:|.| |.::.|.:.:|..:.:     :|.||.|:||:|.
Zfish   839 AIVRDIVMVEKQN----------PSIQPVP-MLEVDPTVFEKRFLKK-----IRDLGEGHFGKVE 887

  Fly   301 YGKW-----RNSIDVAVKTLREGTMSTAA--FLQEAAIMKKFRHNRLVALYAVCSQE--EPIYIV 356
            ..::     |....||||:|:.......:  ..:|..|:::..|..:|....:|::|  ..|.::
Zfish   888 LCRYDPRGDRTGELVAVKSLKPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLI 952

  Fly   357 QEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKI 421
            .|::..|||.::|..... :::.:.|:..:.|:..||:||.|:..|||||||||||:......||
Zfish   953 MEFLPAGSLKEYLPRNKA-HINLKTLLNYSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKI 1016

  Fly   422 CDFGLARVIADDE--YCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTY------- 477
            .||||.:.|.|:|  |..|.....||.|.|||.:|:.||...|||||:|:.:.||.||
Zfish  1017 GDFGLTKSIKDNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSP 1081

  Fly   478 ------------GQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF 530
                        ||     |....:::.:|.|.|:|:|.:  ..:.:|.|:.:||:|.||||..|
Zfish  1082 MSVFLKLIGPTHGQ-----MTVTRLVKVLEEGKRLPRPDD--CSEQLYNLMRRCWEATPEKRINF 1139

  Fly   531 EFLNHYFE 538
            :.|...|:
Zfish  1140 KSLIANFQ 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	9/64 (14%)
		SH2_Src_family	158..259	CDD:199827	21/112 (19%)
		STYKc	285..537	CDD:214568	92/281 (33%)
		PTKc_Src_like	289..538	CDD:270630	92/278 (33%)
jak1	NP_571148.1	B41	35..276	CDD:214604
		FERM_C_JAK1	280..422	CDD:275412
		SH2_Jak1	422..523	CDD:198241
		PTK_Jak1_rpt1	580..845	CDD:270662	40/200 (20%)
		Pkinase_Tyr	580..844	CDD:285015	40/199 (20%)
		PKc_like	867..1150	CDD:304357	94/294 (32%)
		Pkinase_Tyr	872..1146	CDD:285015	92/286 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810