Protein Alignment Src64B and Srms

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001011961.1
• Gene: Srms / 296472
• RGDID: 1306602
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 439
• Identity: 196/439 - (44%)
• Similarity: 271/439 - (61%)
• Gaps: 19/439 - (4%)

  Fly    98 RVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLT-TRQEGLIPLNFVAE--ERSVNS 159
            |:..||||:.:|...:||..:|||:..:.: |.::.....|: ....||:|:.::|:  ..:.:.
  Rat    69 RLFRALYDFTARCAEELSVSRGDRLYALKE-EGEYIFAQRLSGPPSTGLVPVTYLAKATPETPSD 132

  Fly   160 EDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNG 224
            :.|:|..:.|.:|.:|||:..|..|.||:||||.:..||||||:     ....|.||||....:|
  Rat   133 QPWYFNGISRTQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVR-----AQAKVCHYRICMAPSG 192

  Fly   225 GYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLR 289
            |.|:...:.||||.|| :||.|.|...:.:.|.:||   .|||    |..:|::|.||||..|.|
  Rat   193 GLYLQEGRLFPSLDAL-LAYYKTNWKLIQNPLLQPC---VPQM----PLAQDEWERPRSEFVLRR 249

  Fly   290 KLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIY 354
            |||.|.||||:.|.|..|..||||.::...|..|...:|...:|..||.||:.|:|:||..||:|
  Rat   250 KLGEGFFGEVWEGLWLGSTPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVY 314

  Fly   355 IVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVA 419
            ||.|.|.||:|..:|...:|:.|....|:..|.|||.||.|||.::::||||||||||:|::...
  Rat   315 IVTELMGKGNLQVYLGSPEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTC 379

  Fly   420 KICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPG 484
            |:.||||||::.||.|.|..||:.|||||||||..|..||.||||||:||||.|:|||||.||.|
  Rat   380 KVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEG 444

  Fly   485 MHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            |.:.|.::.|.||:|:|:|.  ..|..:|.|:::||...||:||||..|
  Rat   445 MTNHETLQQISRGYRLPRPA--VCPAEVYMLMVECWKGSPEERPTFATL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	40/100 (40%)
		PTKc_Src_like	289..538	CDD:270630	126/245 (51%)
		SH3_Src_like	99..150	CDD:212779	15/51 (29%)
Srms	NP_001011961.1	SH3	70..124	CDD:473055	15/54 (28%)
		SH2	134..212	CDD:472789	36/83 (43%)
		PTKc_Srm_Brk	238..498	CDD:133248	132/256 (52%)