Protein Alignment Src64B and GRB2

DIOPT Version :9

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_002077.1
• Gene: GRB2 / 2885
• HGNCID: 4566
• Length: 217
• Species: Homo sapiens
• Alignment Length: 209
• Identity: 59/209 - (28%)
• Similarity: 105/209 - (50%)
• Gaps: 43/209 - (20%)

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVI-DDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFF 164
            :|.||:|:..:.:|||.:||.::|: ::.:.:|::..  ...::|.||.|::    .:....|||
Human     4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKPHPWFF 62

  Fly   165 ENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIA 229
            ..:.|.:|:: :|:::...|.||:|.||..|..:|||||...|     |:|:::. .|..|.|..
Human    63 GKIPRAKAEE-MLSKQRHDGAFLIRESESAPGDFSLSVKFGND-----VQHFKVL-RDGAGKYFL 120

  Fly   230 TNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPR--SEIQLL---- 288
            ....|.||..|| .|.:..:      :||     ..|::     |||..::|:  :.:|.|
Human   121 WVVKFNSLNELV-DYHRSTS------VSR-----NQQIF-----LRDIEQVPQQPTYVQALFDFD 168

  Fly   289 ----RKLG--RGNF 296
                .:||  ||:|
Human   169 PQEDGELGFRRGDF 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/49 (29%)
		SH2_Src_family	158..259	CDD:199827	31/100 (31%)
		STYKc	285..537	CDD:214568	7/22 (32%)
		PTKc_Src_like	289..538	CDD:270630	5/10 (50%)
GRB2	NP_002077.1	SH3_GRB2_N	1..56	CDD:212879	15/57 (26%)
		SH2_Grb2_like	56..150	CDD:199828	34/117 (29%)
		SH3_GRB2_C	160..212	CDD:212882	7/23 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910