DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Map3k12

DIOPT Version :9

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_001157115.1 Gene:Map3k12 / 26404 MGIID:1346881 Length:888 Species:Mus musculus


Alignment Length:294 Identity:96/294 - (32%)
Similarity:150/294 - (51%) Gaps:40/294 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAI--MKKFRHN 338
            |.:|:|..||..|:.:|.|..|.||.|::... :||||.:|:        |:|..|  ::|.:|.
Mouse   149 DLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE-EVAVKKVRD--------LKETDIKHLRKLKHP 204

  Fly   339 RLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIH 403
            .::....||:|.....|:.|:.::|.|.:.||.  ||.:....|:..:..:|.||.||...::||
Mouse   205 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLHKIIH 267

  Fly   404 RDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYG 468
            |||.:.|:||..::|.||.|||.::.::|..  .|......|.|.|||.|.....|.|.|:||:|
Mouse   268 RDLKSPNMLITYDDVVKISDFGTSKELSDKS--TKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFG 330

  Fly   469 ILLMELFTYGQVPYPGMHSREVIENI-ERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF-E 531
            ::|.||.| |::||..:.|..:|..: .....:|.|::  .||....||.|||::.|..||:| :
Mouse   331 VVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSS--CPDGFKILLRQCWNSKPRNRPSFRQ 392

  Fly   532 FLNH---------------YFESFSVTSEVPYRE 550
            .|.|               ||:     |:..:||
Mouse   393 ILLHLDIASADVLSTPQETYFK-----SQAEWRE 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH3_Src_like 99..150 CDD:212779
SH2_Src_family 158..259 CDD:199827
STYKc 285..537 CDD:214568 87/270 (32%)
PTKc_Src_like 289..538 CDD:270630 86/267 (32%)
Map3k12NP_001157115.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..104
STKc_MAP3K12_13 164..400 CDD:270961 85/251 (34%)
Leucine-zipper 1 423..444
Leucine-zipper 2 476..497
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 557..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..888
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X88
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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