DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Hck

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_037317.2	Gene:	Hck / 25734	RGDID:	2785	Length:	524	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	232/500 - (46%)
Similarity:	336/500 - (67%)	Gaps:	14/500 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVV---LKRVVVALYDYKSRDESDLSF 116
            ||..|:..|:.|.:||:.:........:.|.:..:..||||   ...:|||||||::....||||
  Rat    33 GSKASKIEPNANQKGPVYVPDPTSPKKLGPNSINSLPPGVVEGSEDTIVVALYDYEAIHREDLSF 97

  Fly   117 MKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEEN 181
            .|||:|.|:::: .:||:..:|.|::||.||.|:||...|:.:|:|||:.:.||:|::.|||..|
  Rat    98 QKGDQMVVLEES-GEWWKARSLATKKEGYIPSNYVARVNSLETEEWFFKGISRKDAERHLLAPGN 161

  Fly   182 PRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSK 246
            ..|:|::|.||.....|||||:|::...|..||||:|:.||:||:||:...||.|||.||:.| |
  Rat   162 MLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVVHY-K 225

  Fly   247 ENALGLCHILSRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDV 310
            :...|||..||.||..|:||. |:     :|.:||||..:|:.:|||.|.||||:...:.....|
  Rat   226 KGKDGLCQKLSVPCVSPKPQKPWE-----KDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKV 285

  Fly   311 AVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGR 375
            ||||::.|:||..|||.||.:||..:|::||.|:||.|| |||:||.|:|:||||||||:..:|.
  Rat   286 AVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQ-EPIFIVTEFMAKGSLLDFLKSEEGS 349

  Fly   376 YLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQG 440
            ......||..:.|::.||.::|.:..|||||.|.|:|:..:.|.||.||||||:|.|:||..::|
  Rat   350 KQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREG 414

  Fly   441 SRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTN 505
            ::||:||||||||.:|.|:|||||||:||||||:.|||::|||||.:.|||..:|.|:|||:|.|
  Rat   415 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDN 479

  Fly   506 HYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
              .|:.:|.::::||...||:|||||::....:.|...:|..|::
  Rat   480 --CPEELYSIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	24/50 (48%)
		SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		STYKc	285..537	CDD:214568	130/251 (52%)
		PTKc_Src_like	289..538	CDD:270630	129/248 (52%)
Hck	NP_037317.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..71		6/35 (17%)
		SH3	80..135	CDD:302595	27/55 (49%)
		SH2_Src_HCK	138..241	CDD:198226	50/103 (49%)
		PKc_like	252..522	CDD:304357	137/272 (50%)
		Pkinase_Tyr	260..509	CDD:285015	130/251 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6609
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820