DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Hck

DIOPT Version :10

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_037317.2 Gene:Hck / 25734 RGDID:2785 Length:524 Species:Rattus norvegicus


Alignment Length:500 Identity:232/500 - (46%)
Similarity:336/500 - (67%) Gaps:14/500 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 GSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVV---LKRVVVALYDYKSRDESDLSF 116
            ||..|:..|:.|.:||:.:........:.|.:..:..||||   ...:|||||||::....||||
  Rat    33 GSKASKIEPNANQKGPVYVPDPTSPKKLGPNSINSLPPGVVEGSEDTIVVALYDYEAIHREDLSF 97

  Fly   117 MKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEEN 181
            .|||:|.|:::: .:||:..:|.|::||.||.|:||...|:.:|:|||:.:.||:|::.|||..|
  Rat    98 QKGDQMVVLEES-GEWWKARSLATKKEGYIPSNYVARVNSLETEEWFFKGISRKDAERHLLAPGN 161

  Fly   182 PRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSK 246
            ..|:|::|.||.....|||||:|::...|..||||:|:.||:||:||:...||.|||.||:.| |
  Rat   162 MLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVVHY-K 225

  Fly   247 ENALGLCHILSRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDV 310
            :...|||..||.||..|:||. |:     :|.:||||..:|:.:|||.|.||||:...:.....|
  Rat   226 KGKDGLCQKLSVPCVSPKPQKPWE-----KDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKV 285

  Fly   311 AVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGR 375
            ||||::.|:||..|||.||.:||..:|::||.|:||.|| |||:||.|:|:||||||||:..:|.
  Rat   286 AVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQ-EPIFIVTEFMAKGSLLDFLKSEEGS 349

  Fly   376 YLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQG 440
            ......||..:.|::.||.::|.:..|||||.|.|:|:..:.|.||.||||||:|.|:||..::|
  Rat   350 KQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREG 414

  Fly   441 SRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTN 505
            ::||:||||||||.:|.|:|||||||:||||||:.|||::|||||.:.|||..:|.|:|||:|.|
  Rat   415 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDN 479

  Fly   506 HYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
              .|:.:|.::::||...||:|||||::....:.|...:|..|::
  Rat   480 --CPEELYSIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQ 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH2_Src_family 158..259 CDD:199827 48/100 (48%)
PTKc_Src_like 289..538 CDD:270630 129/248 (52%)
SH3_Src_like 99..150 CDD:212779 24/50 (48%)
HckNP_037317.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..71 6/35 (17%)
SH3 80..135 CDD:473055 27/55 (49%)
SH2_Src_HCK 138..241 CDD:198226 50/103 (49%)
Protein Kinases, catalytic domain 252..522 CDD:473864 137/272 (50%)
Blue background indicates that the domain is not in the aligned region.

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