DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and FYN

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001357458.1	Gene:	FYN / 2534	HGNCID:	4037	Length:	537	Species:	Homo sapiens

Alignment Length:	530	Identity:	258/530 - (48%)
Similarity:	354/530 - (66%)	Gaps:	47/530 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TFGQTHI------NSSGGGNM---GGVLGQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRP 84
            :||.|.|      :::||..:   |||      |..|          |.|.|:..|..||.:.
Human    41 SFGVTSIPNYNNFHAAGGQGLTVFGGV------NSSS----------HTGTLRTRGGTGVTLF-- 87

  Fly    85 RTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLN 149
                            ||||||::|.|.||||.||::.::::.:|.|||...:|||.:.|.||.|
Human    88 ----------------VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSN 136

  Fly   150 FVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVK 214
            :||...|:.:|:|:|..:.||:|::.||:..|||||||:|.||.....||||::||:|.:|.|||
Human   137 YVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVK 201

  Fly   215 HYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYE 279
            ||:|:.||||||||.|...|.:||.||..|| |.|.|||..|..||.|..|::.||..:.:|.:|
Human   202 HYKIRKLDNGGYYITTRAQFETLQQLVQHYS-ERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265

  Fly   280 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALY 344
            |||..:||:::||.|.||||:.|.|..:..||:|||:.||||..:||:||.||||.:|::||.||
Human   266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY 330

  Fly   345 AVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAAR 409
            ||.| |||||||.|||:||||||||::|:||.|...:|:.:|.|||:||.|:|....|||||.:.
Human   331 AVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSA 394

  Fly   410 NVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMEL 474
            |:|:|...:.||.||||||:|.|:||..:||::||:|||||||.:||:|:|||||||:||||.||
Human   395 NILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL 459

  Fly   475 FTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFES 539
            .|.|:||||||::|||:|.:|||:|||.|.:  .|.::::|::.||...||:|||||:|..:.|.
Human   460 VTKGRVPYPGMNNREVLEQVERGYRMPCPQD--CPISLHELMIHCWKKDPEERPTFEYLQSFLED 522

  Fly   540 FSVTSEVPYR 549
            :...:|..|:
Human   523 YFTATEPQYQ 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	24/50 (48%)
		SH2_Src_family	158..259	CDD:199827	54/100 (54%)
		STYKc	285..537	CDD:214568	145/251 (58%)
		PTKc_Src_like	289..538	CDD:270630	143/248 (58%)
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939	26/72 (36%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	54/100 (54%)
		PTKc_Fyn	261..534	CDD:270655	153/275 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6763
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730