DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Jak2

DIOPT Version :10

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_113702.1 Gene:Jak2 / 24514 RGDID:2939 Length:1132 Species:Rattus norvegicus


Alignment Length:669 Identity:161/669 - (24%)
Similarity:266/669 - (39%) Gaps:183/669 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KCC-SKRQDQELALAYPTGGYKKSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLDSRYTPDPNH 67
            ||| .|.:|:...|.:.|.|.  ||.....|.              |:|||...:...       
  Rat   497 KCCPPKPKDKSNLLVFRTNGV--SDVQLSPTL--------------QRHNNVNQMVFH------- 538

  Fly    68 RGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDW 132
                ||..:   |:|...:...|....:.|.|...:.||....|:::      .::|:|....::
  Rat   539 ----KIRNE---DLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEV------LLKVLDKAHRNY 590

  Fly   133 ----WRVVNLTTR----------------QEGLIPLNFV-------------------------- 151
                :...::.::                :|.::...||                          
  Rat   591 SESFFEAASMMSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAK 655

  Fly   152 --------AEERSVNSEDWFFENVL------RKEADKLLLAEENPRGTFLVRPSE---------- 192
                    .||:|:...:...:|:|      ||..:...:...:|..:..|.|.:          
  Rat   656 QLAWAMHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP 720

  Fly   193 ----HNPNGYSLSVKDWEDG-----------------------RGYHVKHYRIKP----LDNGGY 226
                .||...:|:...|..|                       :.|..||....|    |.|   
  Rat   721 PECIENPKNLTLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELAN--- 782

  Fly   227 YIATNQTF-----PSLQALVMAYSKENALGL--CHILSRPCPKPQPQMWDLG----PELRDKYEI 280
            .|.|...:     |:.:|::...   |:|..  ..:|:.....|..::..||    .|.||..:.
  Rat   783 LINTCMDYEPDFRPAFRAVIRDL---NSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQF 844

  Fly   281 PRSEIQLLRKLGRGNFGEVFYGKWRNSID-----VAVKTLREGTMS-TAAFLQEAAIMKKFRHNR 339
            ....::.|::||:||||.|...::....|     ||||.|:..|.. ...|.:|..|:|..:|:.
  Rat   845 EERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDN 909

  Fly   340 LVALYAVC--SQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLI 402
            :|....||  :....:.::.||:..|||.|:|::...|..| :.|:...:|:..|||||.:|:.|
  Rat   910 IVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDH-KKLLQYTSQICKGMEYLGTKRYI 973

  Fly   403 HRDLAARNVLIGENNVAKICDFGLARVIADDE--YCPKQGSRFPVKWTAPEAIIYGKFSIKSDVW 465
            |||||.||:|:...|..||.||||.:|:..|:  |..|:....|:.|.|||::...|||:.||||
  Rat   974 HRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVW 1038

  Fly   466 SYGILLMELFTYGQ------VPYPGMHSRE---------VIENIERGFRMPKPTNHYFPDNIYQL 515
            |:|::|.|||||.:      |.:..|...:         :||.::...|:|:|..  .||.||.:
  Rat  1039 SFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPEG--CPDEIYVI 1101

  Fly   516 LLQCWDAVPEKRPTFEFLN 534
            :.:||:....:||:|..|:
  Rat  1102 MTECWNNNVNQRPSFRDLS 1120

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH2_Src_family 158..259 CDD:199827 25/154 (16%)
PTKc_Src_like 289..538 CDD:270630 96/271 (35%)
SH3_Src_like 99..150 CDD:212779 7/70 (10%)
Jak2NP_113702.1 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..239
FERM_F1 39..134 CDD:465733
FERM_F2 143..261 CDD:436450
FERM_C_JAK2 266..386 CDD:270141
SH2_Jak2 386..482 CDD:198242
PTK_Jak2_rpt1 545..806 CDD:270663 37/272 (14%)
PTKc_Jak2_rpt2 844..1127 CDD:271107 97/280 (35%)
Blue background indicates that the domain is not in the aligned region.

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