DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Yes1

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001192061.1	Gene:	Yes1 / 22612	MGIID:	99147	Length:	541	Species:	Mus musculus

Alignment Length:	558	Identity:	265/558 - (47%)
Similarity:	360/558 - (64%)	Gaps:	31/558 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKCCSKRQDQELALAYP----TGGYKKSDYTFGQTH-----INSSGGGNMGGVLGQKHNNGGS 56
            ||  |...::::..|:.|.    |.....|...:|..|     .:|:.|.::         |..|
Mouse     1 MG--CIKSKENKSPAIKYTPENLTEPVSPSASHYGVEHATVAPTSSTKGASV---------NFNS 54

  Fly    57 LDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDR 121
            |.  .||.....|....||......:...:.|||:.|.|  .:.||||||::|...||||.||:|
Mouse    55 LS--MTPFGGSSGVTPFGGASSSFSVVSSSYPTGLTGGV--TIFVALYDYEARTTEDLSFKKGER 115

  Fly   122 MEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTF 186
            .::|::||.|||...::.|.:.|.||.|:|....|:.:|:|:|..:.||:|::|||...|.||.|
Mouse   116 FQIINNTEGDWWEARSIATGKSGYIPSNYVVPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIF 180

  Fly   187 LVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALG 251
            |||.||.....||||::||::.||.:||||:|:.||||||||.|...|.:||.||..|: |:|.|
Mouse   181 LVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYT-EHADG 244

  Fly   252 LCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR 316
            |||.|:..||..:||...|.   :|.:||||..::|..|||:|.||||:.|.|..:..||:|||:
Mouse   245 LCHKLTTVCPTVKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK 306

  Fly   317 EGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFED 381
            .|||...||||||.||||.||::||.||||.| |||||||.|:||||||||||:||||:||....
Mouse   307 PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQ 370

  Fly   382 LIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVK 446
            |:.:|.|:|.||.|:|....|||||.|.|:|:|||.:.||.||||||:|.|:||..:||::||:|
Mouse   371 LVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIK 435

  Fly   447 WTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDN 511
            ||||||.:||:|:|||||||:|||..||.|.|:||||||.:|||:|.:|||:|||.|..  .|::
Mouse   436 WTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG--CPES 498

  Fly   512 IYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            :::|:..||...|::|||||::..:.|.:...:|..|:
Mouse   499 LHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	24/50 (48%)
		SH2_Src_family	158..259	CDD:199827	53/100 (53%)
		STYKc	285..537	CDD:214568	148/251 (59%)
		PTKc_Src_like	289..538	CDD:270630	147/248 (59%)
Yes1	NP_001192061.1	SH3_Yes	92..149	CDD:212940	26/56 (46%)
		SH2_Src_family	152..251	CDD:199827	53/99 (54%)
		PTKc_Yes	262..540	CDD:270654	157/281 (56%)
		Pkinase_Tyr	275..524	CDD:285015	148/251 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6752
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780