DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and Txk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_036020891.1	Gene:	Txk / 22165	MGIID:	102960	Length:	543	Species:	Mus musculus

Alignment Length:	515	Identity:	190/515 - (36%)
Similarity:	278/515 - (53%)	Gaps:	70/515 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LGQKH-----------------NNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGV 94
            |.:||                 |.||...|:..|.|    ||            |:..|.
Mouse    68 LSEKHSQRQRPWFAKLMGKTQSNRGGVQPSKRKPLP----PL------------PQEPPD----- 111

  Fly    95 VLKRV-VVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVN 158
              :|: |.||||:..|:..:|:..:.:...:::..:..||:..: ....|||||.|:|.|.|..|
Mouse   112 --ERIQVKALYDFLPREPGNLALKRAEEYLILERCDPHWWKARD-RFGNEGLIPSNYVTENRLAN 173

  Fly   159 SE--DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGY---HVKHYRI 218
            .|  :|:.:|:.|.:.:: ||.:|...|.|:||.|.| ...|::||  :...|.:   .:|||:|
Mouse   174 LEIYEWYHKNITRNQTER-LLRQEAKEGAFIVRDSRH-LGSYTISV--FTRARRHTQSSIKHYQI 234

  Fly   219 KPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPEL-------RD 276
            |..|:|.:||.....|||:..|:. |.:.||.||...|..|       :..||..|       .:
Mouse   235 KKNDSGQWYITERHLFPSVPELIQ-YHQYNAAGLISRLRYP-------IGLLGSCLPATSGFSYE 291

  Fly   277 KYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLV 341
            |:||..||:..::::|.|.||.|..|:||..|.||:|.:.||:||...|::||.:|.|..|:|||
Mouse   292 KWEIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLV 356

  Fly   342 ALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDL 406
            .||.||.|::|:|||.|:|..|.|||:|||..|: |....|:.:...:..||.|||....|||||
Mouse   357 QLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQ-LQKALLLSMCQDICEGMAYLERSCYIHRDL 420

  Fly   407 AARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILL 471
            ||||.|:....|.||.|||:||.:.||||....|::|||||..||...:.|:|.||||||:|:|:
Mouse   421 AARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLM 485

  Fly   472 MELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFE 531
            .|:||.|::|:....:.:|:|.|.:|||:.:|  |..|..||:::..||....:| |.|:
Mouse   486 WEVFTEGKMPFENKSNLQVVEAISQGFRLYRP--HLAPMTIYRVMYSCWHETLQK-PVFQ 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/51 (27%)
		SH2_Src_family	158..259	CDD:199827	37/105 (35%)
		STYKc	285..537	CDD:214568	112/247 (45%)
		PTKc_Src_like	289..538	CDD:270630	112/243 (46%)
Txk	XP_036020891.1	SH3_TXK	114..168	CDD:212840	16/54 (30%)
		SH2_Tec_Txk	172..277	CDD:198261	38/116 (33%)
		PKc_like	295..543	CDD:419665	115/252 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810