DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Tec

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001106931.1	Gene:	Tec / 21682	MGIID:	98662	Length:	630	Species:	Mus musculus

Alignment Length:	466	Identity:	182/466 - (39%)
Similarity:	262/466 - (56%)	Gaps:	28/466 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 IRPRTTPTGVPGVV--LKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEG 144
            |:.|..|..:|...  .:.:|||:||:::.:..||...:|....:::..:..|||..: ....||
Mouse   163 IKKRRPPPPIPPEEENTEEIVVAMYDFQATEAHDLRLERGQEYIILEKNDLHWWRARD-KYGSEG 226

  Fly   145 LIPLNFVAEERSVNSE--DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWED 207
            .||.|:|..::|.|.:  :|:..|..|.:|::||..|:. .|.|:||.|. .|..|::|:.....
Mouse   227 YIPSNYVTGKKSNNLDQYEWYCRNTNRSKAEQLLRTEDK-EGGFMVRDSS-QPGLYTVSLYTKFG 289

  Fly   208 GRG------YHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQ 266
            |.|      ||:|.....|..   ||:|....|.|:..:: .|.|.||.||...|..|.......
Mouse   290 GEGSSGFRHYHIKETATSPKK---YYLAEKHAFGSIPEII-EYHKHNAAGLVTRLRYPVSTKGKN 350

  Fly   267 MWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAI 331
            .........||:||..||:..:|:||.|.||.|..||||....||:|.:|||.|....|::||.:
Mouse   351 APTTAGFSYDKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKV 415

  Fly   332 MKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHF--EDLIYIATQVASGME 394
            |.|..|.:||.||.||:|::|||||.|:|.:|.||:|||:..|   ||  :.|:.:...|..|||
Mouse   416 MMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG---HFSRDMLLSMCQDVCEGME 477

  Fly   395 YLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFS 459
            |||....|||||||||.|:.|..|.|:.|||:||.:.||:|....|::|||||..||...|.:||
Mouse   478 YLERNSFIHRDLAARNCLVNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFS 542

  Fly   460 IKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRM--PKPTNHYFPDNIYQLLLQCWDA 522
            .||||||:|:|:.|:||.|::|:....:.||:..:.||.|:  ||..:.|    :|:::|:||..
Mouse   543 SKSDVWSFGVLMWEIFTEGRMPFEKNTNYEVVTMVTRGHRLHRPKLASKY----LYEVMLRCWQE 603

  Fly   523 VPEKRPTFEFL 533
            .||.||:||.|
Mouse   604 RPEGRPSFEDL 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	15/50 (30%)
		SH2_Src_family	158..259	CDD:199827	34/108 (31%)
		STYKc	285..537	CDD:214568	119/253 (47%)
		PTKc_Src_like	289..538	CDD:270630	119/249 (48%)
Tec	NP_001106931.1	PH_Btk	7..148	CDD:269944
		SH3_Tec	182..236	CDD:212838	17/54 (31%)
		SH2_Tec_Itk	239..346	CDD:198259	35/112 (31%)
		PTKc_Tec_Rlk	364..623	CDD:270685	122/258 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810