DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Y47G6A.5

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_491175.2	Gene:	Y47G6A.5 / 189992	WormBaseID:	WBGene00021635	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	171/548 - (31%)
Similarity:	271/548 - (49%)	Gaps:	108/548 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NGGSLDSRYTPDP-----NHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDES 112
            ||.|    ::|.|     :|.|..|..          .:.|.       :::::....:.::...
Worm   112 NGAS----FSPRPVSKTHSHHGSAKCS----------HSEPE-------EKMLIVENRFLAQTPK 155

  Fly   113 DLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFV--AEERSVNSEDWFFENVLRKEADKL 175
            ::|..:||.:.:|:.:..:||.|.:.:.:.:|.:|.:.|  ||.|    |.||..|:....|::.
Worm   156 EMSVEEGDVLYLIEQSNREWWYVASKSRQFKGFVPKSHVVYAEYR----EPWFAGNISSILAEQR 216

  Fly   176 LLAEENPRGTFLVRP------------SEHN--PNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGY 226
            ::..:.|.|:||:|.            |.||  |..|.:               || :| :..|:
Worm   217 VMQPQLPIGSFLIRENSKTDTFVLVVRSSHNESPQAYII---------------YR-RP-NQEGF 264

  Fly   227 YIATNQT-----FPSLQALVMAYSKENALG---LCHILSRPCPKPQPQMWDLGPELRDKYEIPRS 283
            .|..|..     |.||..||..||.|...|   :|..|::..| |.|:..:.  ....|..:.||
Worm   265 EIRDNHRPAVIHFGSLHQLVNHYSCEKVPGEIQICTKLTKAAP-PLPEQTEY--MAMKKIHVNRS 326

  Fly   284 EIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR---EGTMSTAAFLQEAAIMKKFRHNRLVALYA 345
            |::.::::|||.||||:..||: .:|||||:|:   ...::...||:||..:.|..|..::.|.|
Worm   327 EVRRVKEIGRGQFGEVYLAKWK-GVDVAVKSLKPDHSEQLANTQFLEEAKTLTKLSHQNVIHLLA 390

  Fly   346 VCSQEEPIYIVQEYMSKGSLLDFLR-------------EGDGRYLHFEDLIY---IATQVASGME 394
            ||..::|..|:.|:|:.||||.:|:             |..||    ::::.   |:.||||||:
Worm   391 VCDTDKPYLIITEFMTNGSLLAWLQKLTKTLPPIPLMSEETGR----KNVLIGASISAQVASGMD 451

  Fly   395 YLESKQLIHRDLAARNVLIG---ENNV--AKICDFGLARV--IADDEYCPKQGSRFPVKWTAPEA 452
            ||.:.:::||||||||||:|   .|.|  .|:.||||||.  :.|:.|..|..:..|.||.|||.
Worm   452 YLSANKIVHRDLAARNVLVGTVSSNGVPLVKVADFGLARKTDVGDENYVMKTDNMLPWKWMAPEC 516

  Fly   453 IIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLL 517
            .....|:.|:|||||||||.|:.|.|:.||.|......:|::.||:.:|:|  ...||.:|:...
Worm   517 FDEQIFNTKTDVWSYGILLWEIGTLGKTPYRGWDYEGTLEHLSRGYVLPRP--ELVPDYVYEDAF 579

  Fly   518 Q-CWDAVPEKRPTFEFLNHYFESFSVTS 544
            : |....|.:||||:.|..||:..:..|
Worm   580 KICVHLDPRRRPTFDRLFKYFDEINCES 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	9/50 (18%)
		SH2_Src_family	158..259	CDD:199827	32/122 (26%)
		STYKc	285..537	CDD:214568	107/278 (38%)
		PTKc_Src_like	289..538	CDD:270630	108/275 (39%)
Y47G6A.5	NP_491175.2	SH3	151..194	CDD:302595	9/42 (21%)
		SH2	201..305	CDD:301589	32/120 (27%)
		TyrKc	328..600	CDD:197581	107/278 (38%)
		PTKc	332..601	CDD:270623	108/275 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920