Protein Alignment Src64B and hir-1

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_504458.1
• Gene: hir-1 / 178936
• WormBaseID: WBGene00016059
• Length: 903
• Species: Caenorhabditis elegans
• Alignment Length: 520
• Identity: 162/520 - (31%)
• Similarity: 232/520 - (44%)
• Gaps: 120/520 - (23%)

  Fly   115 SFMKGDRMEVIDDTESDWWRVVNLT----TRQEGLIPLNFV-----AEERSVNSEDWF----FEN 166
            |.:..|| |.::|..|:  ..||:|    ||...:..|.::     |.|.....|:.|    ..:
 Worm   331 SVLSRDR-ENLNDPASN--LTVNVTFIPVTRNNEMPTLYYIGIFGTASEYHTKEEETFLGVNITH 392

  Fly   167 VLRKEADKL-------LLAEENPRGTFLVRPSEHNPNGYSL---SVKDWE---------DGRGYH 212
            |:.||:...       .|||...|.  :|....|....|.|   :|||..         |.:.:.
 Worm   393 VIGKESSCTGFDSSGNCLAENLNRS--IVLQGIHPKTLYGLTICAVKDIRNLTLPDVTLDSKSFR 455

  Fly   213 VKHYRIKPL---DNGGYYIATNQTFPSLQALVMA------YSKENALGLCHILSRPCPKPQPQMW 268
            .|..||..:   .|....:.......||..:::|      |.::.:..:         |.:.||.
 Worm   456 AKADRIMLVAHTSNNPVGMIIGIVIGSLVVILVAIVVIWFYFRKKSENM---------KFKFQME 511

  Fly   269 DLGPELRDKY-------------EIPRSEIQLL--RKLGRGNFGEVFYGKW-------------- 304
            .:|....::|             ||.|..:.:.  :|||.|.||.|:.||.
 Worm   512 QVGKNNMNRYIDFPIMAAKNDIWEIERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPL 576

  Fly   305 ------RNSIDVAVKTLRE--GTMSTAAFLQEAAIMKKF-RHNRLVALYAVCSQEEPIYIVQEYM 360
                  ..:..||||.|.|  ..||...||:|.|:||.. .|.|||.:.|..::.||:.:|.||.
 Worm   577 GINLMRAENCQVAVKMLPEYADEMSKHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVEYC 641

  Fly   361 SKGSLLDFLREG-------DGRYLHFED-----------------LIYIATQVASGMEYLESKQL 401
            ..|.||.||||.       |...:::.|                 |:..|.|::.|:|||..|..
 Worm   642 DNGDLLKFLRERCKYMMKLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQKGF 706

  Fly   402 IHRDLAARNVLIGENNVAKICDFGLARVI-ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVW 465
            :|||:||||||:.|....||.||||.|.| ||......:|.:.|:||.:||||.:.:||||||:|
 Worm   707 VHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQYKSKGGKLPLKWMSPEAIRHYEFSIKSDIW 771

  Fly   466 SYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF 530
            |:||||.|:.|.|..|||||...:|:..:|.|.|:.||.|  .|:|.|.:::|||:|.|:.|..|
 Worm   772 SFGILLFEVITLGGSPYPGMPPEDVLPFLEGGGRIEKPDN--CPENFYDVMMQCWNADPDDRIEF 834

  Fly   531  530
             Worm   835  834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	25/132 (19%)
		PTKc_Src_like	289..538	CDD:270630	115/290 (40%)
		SH3_Src_like	99..150	CDD:212779	12/38 (32%)
hir-1	NP_504458.1	fn3	85..164	CDD:394996
		RGP	227..>281	CDD:385243
		PTKc	547..842	CDD:270623	115/290 (40%)