DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and dlk-1

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001021443.1	Gene:	dlk-1 / 173128	WormBaseID:	WBGene00001008	Length:	928	Species:	Caenorhabditis elegans

Alignment Length:	308	Identity:	91/308 - (29%)
Similarity:	137/308 - (44%)	Gaps:	49/308 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFL 326
            |.:.::|          |||...|..|..||.|:.|.||.|:..|. .||||.:.:        |
Worm   122 KSEDELW----------EIPFDAISELEWLGSGSQGAVFRGQLENR-TVAVKKVNQ--------L 167

  Fly   327 QEAAI--MKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQV 389
            :|..|  ::..||..::....|||:.....||.||.|||.|...|:..:  .:..|.......::
Worm   168 KETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSRN--TITRELFAQWVKEI 230

  Fly   390 ASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDE-----YCPKQGSRFPVKWTA 449
            |.||.||...::|||||.:.|:||...:..||||||.:.:....:     :|   |:   |.|.|
Worm   231 ADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFC---GT---VSWMA 289

  Fly   450 PEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERG-FRMPKPTNHYFPDNIY 513
            ||.|.....:.|.||:|:|::|.|:.| .:.||..:....:|..:... ..:|.|..  .|..:.
Worm   290 PEMIKKQPCNEKVDVYSFGVVLWEMLT-RETPYANIAQMAIIFGVGTNILSLPMPEE--APKGLV 351

  Fly   514 QLLLQCWDAVPEKRPTFEFLNHYF-----ESFSVTSEV------PYRE 550
            .|:.||.......||:|..:..::     |.|.:|.|.      .|||
Worm   352 LLIKQCLSQKGRNRPSFSHIRQHWEIFKPELFEMTEEEWQLAWDSYRE 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779
		SH2_Src_family	158..259	CDD:199827
		STYKc	285..537	CDD:214568	79/259 (31%)
		PTKc_Src_like	289..538	CDD:270630	77/261 (30%)
dlk-1	NP_001021443.1	PKc_like	141..377	CDD:304357	77/255 (30%)
dlk-1	NP_001021443.1	S_TKc	141..374	CDD:214567	77/252 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910