DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Lck

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001155904.1	Gene:	Lck / 16818	MGIID:	96756	Length:	520	Species:	Mus musculus

Alignment Length:	479	Identity:	224/479 - (46%)
Similarity:	321/479 - (67%)	Gaps:	16/479 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 KGGVDIIRPRTTPTG--VPGVVLK-RVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVN 137
            :.|.::..|..|..|  .|...|: .:|:||:.|:...:.||.|.||:::.:::.: .:||:..:
Mouse    50 RNGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQS 113

  Fly   138 LTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV 202
            |||.|||.||.||||:..|:..|.|||:|:.||:|::.|||..|..|:||:|.||.....:||||
Mouse   114 LTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV 178

  Fly   203 KDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPC--PKPQP 265
            :|::..:|..||||:|:.|||||:||:...|||.|..||..|:..:. |||..|||||  .|||.
Mouse   179 RDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASD-GLCTKLSRPCQTQKPQK 242

  Fly   266 QMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAA 330
            ..|:      |::|:||..::|:.:||.|.||||:.|.:.....||||:|::|:||..|||.||.
Mouse   243 PWWE------DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEAN 301

  Fly   331 IMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEY 395
            :||:.:|.|||.||||.:| |||||:.|||..|||:|||:...|..|:...|:.:|.|:|.||.:
Mouse   302 LMKQLQHPRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAF 365

  Fly   396 LESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSI 460
            :|.:..|||||.|.|:|:.:....||.||||||:|.|:||..::|::||:||||||||.||.|:|
Mouse   366 IEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI 430

  Fly   461 KSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPE 525
            ||||||:||||.|:.|:|::|||||.:.|||:|:|||:||.:|.|  .|:.:|.|::.||...||
Mouse   431 KSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDN--CPEELYHLMMLCWKERPE 493

  Fly   526 KRPTFEFLNHYFESFSVTSEVPYR 549
            .||||::|....:.|...:|..|:
Mouse   494 DRPTFDYLRSVLDDFFTATEGQYQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	19/50 (38%)
		SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		STYKc	285..537	CDD:214568	132/251 (53%)
		PTKc_Src_like	289..538	CDD:270630	131/248 (53%)
Lck	NP_001155904.1	SH3_Lck	76..129	CDD:212938	22/53 (42%)
		SH2_Src_Lck	134..234	CDD:198225	48/100 (48%)
		PTKc_Lck_Blk	248..511	CDD:270652	136/265 (51%)
		Pkinase_Tyr	256..505	CDD:285015	132/251 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6752
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820