DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Jak3

DIOPT Version :9

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_001177759.1 Gene:Jak3 / 16453 MGIID:99928 Length:1100 Species:Mus musculus


Alignment Length:698 Identity:172/698 - (24%)
Similarity:261/698 - (37%) Gaps:199/698 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KCCSKRQDQELALAYPTGGYKKSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLD-------SRY 61
            |.|..|||       |:|.:  |.....|.|      .::..:|....|:|..:|       |..
Mouse   423 KGCLIRQD-------PSGAF--SLVGLSQPH------RSLRELLAACWNSGLRVDGAALNLTSCC 472

  Fly    62 TPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDL---------SFM 117
            .|.|..        |..:.::|...||...||.......:....:.:.....|         ||.
Mouse   473 APRPKE--------KSNLIVVRRGCTPAPAPGCSPSCCALTQLSFHTIPTDSLEWHENLGHGSFT 529

  Fly   118 K---GDRMEVID----DTE--------------SDWWRVVNLTTR-------------------- 141
            |   |.|.||:|    |:|              ..:....:|.::                    
Mouse   530 KIFRGRRREVVDGETHDSEVLLKVMDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDSIM 594

  Fly   142 -QE----GLIPLNFVAEERSVNSEDWFFE---------NVLRKE--------ADKLLLAEE---- 180
             ||    |.|.: ::.:...:.|..|..:         |.|..:        |.|:|||.|    
Mouse   595 VQEFVYLGAIDM-YLRKRGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDG 658

  Fly   181 NPRGTFLVRPSEHNPNGYSLSV------------------------------KDWE--DGRGYHV 213
            ||....|..|.. :|...||.:                              ..||  .|...|:
Mouse   659 NPPFIKLSDPGV-SPTVLSLEMLTDRIPWVAPECLQEAQTLGLEADKWGFGATTWEVFSGGPAHI 722

  Fly   214 KHY----RIKPLDNGGYYIATNQTFPSLQALV---MAYSK----------ENALGLC----HILS 257
            ...    ::|..::.|...|...|  .|..|:   |||..          .:..||.    .:||
Mouse   723 TSLEPAKKLKFYEDQGQLPALKWT--ELAGLITQCMAYDPGRRPSFRAILRDLNGLITSDYELLS 785

  Fly   258 RP---CPKPQPQMWDLGPEL---RDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSID-----VA 311
            .|   .|.|:.::.. |.:|   :|........::.:..||:||||.|...::....|     ||
Mouse   786 DPTPGIPSPRDELCG-GAQLYACQDPAIFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVA 849

  Fly   312 VKTLR-EGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQ---EEPIYIVQEYMSKGSLLDFLREG 372
            ||.|: .|......|.:|..|:|.. |:..:..|...|.   .:.:.:|.||:..|.|.|||:..
Mouse   850 VKQLQHSGPDQQRDFQREIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH 913

  Fly   373 DGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARV--IADDEY 435
            ..| ||.:.|:..|.|:..|||||.:::.:||||||||:|:......||.|||||::  :..|.|
Mouse   914 RAR-LHTDRLLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYY 977

  Fly   436 CPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTY------GQVPYPGMHSRE----- 489
            ..::..:.|:.|.|||::....||.:|||||:|::|.|||||      ....:..|...|     
Mouse   978 VVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLSMMGPEREGPP 1042

  Fly   490 ---VIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLN 534
               ::|.:..|.|:|.|..  .|..:.:|:..||...|..||.|..|:
Mouse  1043 LCRLLELLAEGRRLPPPPT--CPTEVQELMQLCWAPSPHDRPAFGTLS 1088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH3_Src_like 99..150 CDD:212779 16/105 (15%)
SH2_Src_family 158..259 CDD:199827 34/174 (20%)
STYKc 285..537 CDD:214568 93/275 (34%)
PTKc_Src_like 289..538 CDD:270630 93/271 (34%)
Jak3NP_001177759.1 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..223
B41 41..246 CDD:214604
FERM_C_JAK3 250..359 CDD:275413
SH2 359..455 CDD:301589 11/46 (24%)
PKc_like 517..774 CDD:304357 46/260 (18%)
Pkinase_Tyr 517..773 CDD:285015 46/259 (18%)
PKc_like 813..1095 CDD:304357 93/280 (33%)
Pkinase_Tyr 818..1091 CDD:285015 93/275 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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