DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Jak2

DIOPT Version :9

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_001041642.1 Gene:Jak2 / 16452 MGIID:96629 Length:1132 Species:Mus musculus


Alignment Length:655 Identity:167/655 - (25%)
Similarity:263/655 - (40%) Gaps:155/655 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KCC-SKRQDQELALAYPTGGYKKSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLDSRYTPDPNH 67
            ||| .|.:|:...|.:.|.|.  ||.....|.              |:|||...:......:.:.
Mouse   497 KCCPPKPKDKSNLLVFRTNGI--SDVQISPTL--------------QRHNNVNQMVFHKIRNEDL 545

  Fly    68 RGPLKIGGKGGVDIIRPRTTPTGVPGVVLK-RVVVALYDYKSRDESDLSFMKGDRMEVIDDTESD 131
            .....:|......|.:......|..|.:.| .|::.:.|...|:.|:..|.....|..:    |.
Mouse   546 IFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASMMSQL----SH 606

  Fly   132 WWRVVN---LTTRQEGLIPLNFV----------AEERSVN---------SEDW---FFE------ 165
            ...|:|   ....:|.::...||          ..:.|:|         ...|   |.|      
Mouse   607 KHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEEKSLIH 671

  Fly   166 -NVLRKEADKLLLAEE-------------NPRGTFLVRPSE--------------HNPNGYSLSV 202
             ||..|..  ||:.||             :|..:..|.|.:              .||...:|:.
Mouse   672 GNVCAKNI--LLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLAT 734

  Fly   203 KDWEDG-----------------------RGYHVKHYRIKP--------LDNGGYYIATNQTF-P 235
            ..|..|                       :.|..||....|        ::|...|   ...| |
Mouse   735 DKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTELANLINNCMDY---EPDFRP 796

  Fly   236 SLQALVMAYSKENALGL--CHILSRPCPKPQPQMWDLG----PELRDKYEIPRSEIQLLRKLGRG 294
            :.:|::...   |:|..  ..:|:.....|..::..||    .|.||..:.....::.|::||:|
Mouse   797 AFRAVIRDL---NSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKG 858

  Fly   295 NFGEVFYGKWRNSID-----VAVKTLREGTMS-TAAFLQEAAIMKKFRHNRLVALYAVC--SQEE 351
            |||.|...::....|     ||||.|:..|.. ...|.:|..|:|..:|:.:|....||  :...
Mouse   859 NFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRR 923

  Fly   352 PIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGEN 416
            .:.::.||:..|||.|:|::...|..| :.|:...:|:..|||||.:|:.||||||.||:|:...
Mouse   924 NLRLIMEYLPYGSLRDYLQKHKERIDH-KKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENE 987

  Fly   417 NVAKICDFGLARVIADDE--YCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQ 479
            |..||.||||.:|:..|:  |..|:....|:.|.|||::...|||:.|||||:|::|.|||||.:
Mouse   988 NRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIE 1052

  Fly   480 ------VPYPGMHSRE---------VIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPT 529
                  |.:..|...:         :||.::...|:|:|..  .||.||.::.:||:....:||:
Mouse  1053 KSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEG--CPDEIYVIMTECWNNNVSQRPS 1115

  Fly   530 FEFLN 534
            |..|:
Mouse  1116 FRDLS 1120

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH3_Src_like 99..150 CDD:212779 10/53 (19%)
SH2_Src_family 158..259 CDD:199827 31/180 (17%)
STYKc 285..537 CDD:214568 97/275 (35%)
PTKc_Src_like 289..538 CDD:270630 96/271 (35%)
Jak2NP_001041642.1 Interaction with cytokine/interferon/growth hormone receptors 1..239
FERM_F1 39..134 CDD:408179
FERM_F2 143..261 CDD:408177
FERM_C_JAK2 266..386 CDD:270141
SH2_Jak2 386..482 CDD:198242
PTK_Jak2_rpt1 545..806 CDD:270663 46/272 (17%)
PTKc_Jak2_rpt2 844..1127 CDD:271107 97/280 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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