DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Itk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001268894.1	Gene:	Itk / 16428	MGIID:	96621	Length:	625	Species:	Mus musculus

Alignment Length:	487	Identity:	178/487 - (36%)
Similarity:	261/487 - (53%)	Gaps:	54/487 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVID 126
            ||:.|.|           ....|..|           :|:|||||::.|..:|:....:...::|
Mouse   166 TPEDNRR-----------SFQEPEET-----------LVIALYDYQTNDPQELALRCDEEYYLLD 208

  Fly   127 DTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSE--DWFFENVLRKEADKLLLAEENPRGTFLVR 189
            .:|..||||.: ....||..|.:::.|:...|.|  :|:.:::.|.:|:|||| :....|.|:||
Mouse   209 SSEIHWWRVQD-KNGHEGYAPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLL-DTGKEGAFMVR 271

  Fly   190 PSEHNPNGYSLSVKDWEDGRGYH---------VKHYRIKPLDNG--GYYIATNQTFPSLQALVMA 243
            .| ..|..|::||        :.         :|||.||..::.  .||:|....|.|:..|:.
Mouse   272 DS-RTPGTYTVSV--------FTKAIISENPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQ- 326

  Fly   244 YSKENALGLCHILSRP-CPKPQPQMWDLGPELR-DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRN 306
            |.:.|..||...|..| |...|......|  || .|:.|..||:..::::|.|.||.|..|.|.|
Mouse   327 YHQYNGGGLVTRLRYPVCSWRQKAPVTAG--LRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLN 389

  Fly   307 SIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLRE 371
            ...||:||::||.||...|::||.:|.|..|.:||.||.||.::.||.:|.|:|..|.|.|:||.
Mouse   390 KDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRS 454

  Fly   372 GDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYC 436
            ..|.:. .|.|:.:...|..||.|||...:|||||||||.|:|||.|.|:.|||:.|.:.||:|.
Mouse   455 QRGLFA-AETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYT 518

  Fly   437 PKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMP 501
            ...|::|||||.:||...:.::|.||||||:|:|:.|:|:.|::||....:.||:|:|..|||:.
Mouse   519 SSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLY 583

  Fly   502 KPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            ||  .....::||::..||...||.||.|..|
Mouse   584 KP--RLASCHVYQIMNHCWKEKPEDRPPFSQL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	17/50 (34%)
		SH2_Src_family	158..259	CDD:199827	34/113 (30%)
		STYKc	285..537	CDD:214568	110/249 (44%)
		PTKc_Src_like	289..538	CDD:270630	110/245 (45%)
Itk	NP_001268894.1	PH	5..117	CDD:278594
		PH_Btk	7..154	CDD:269944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..174		4/18 (22%)
		SH3_ITK	180..235	CDD:212841	18/66 (27%)
		SH2_Tec_Itk	238..345	CDD:198259	35/117 (30%)
		PTKc_Itk	363..618	CDD:133243	113/254 (44%)
		Pkinase_Tyr	368..617	CDD:285015	110/249 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810