DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and Hck

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_034537.2	Gene:	Hck / 15162	MGIID:	96052	Length:	524	Species:	Mus musculus

Alignment Length:	518	Identity:	234/518 - (45%)
Similarity:	338/518 - (65%)	Gaps:	14/518 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SSGGGNMGGVLGQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVV---LKR 98
            |.|.....|.:..:....||..|:..|..|.:||:.:........:.|..:.:..||.|   ...
Mouse    15 SEGRAPRMGCVKSRFLRDGSKASKTEPSANQKGPVYVPDPTSSSKLGPNNSNSMPPGFVEGSEDT 79

  Fly    99 VVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWF 163
            :|||||||::....||||.|||:|.|:::. .:||:..:|.|::||.||.|:||...|:.:|:||
Mouse    80 IVVALYDYEAIHREDLSFQKGDQMVVLEEA-GEWWKARSLATKKEGYIPSNYVARVNSLETEEWF 143

  Fly   164 FENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYI 228
            |:.:.||:|::.|||..|..|:|::|.||.....|||||:|::...|..||||:|:.||:||:||
Mouse   144 FKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYI 208

  Fly   229 ATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKLG 292
            :...||.|||.||:.| |:...|||..||.||..|:||. |:     :|.:||||..:|:.:|||
Mouse   209 SPRSTFSSLQELVLHY-KKGKDGLCQKLSVPCVSPKPQKPWE-----KDAWEIPRESLQMEKKLG 267

  Fly   293 RGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQ 357
            .|.||||:...:.....|||||::.|:||..|||.||.:||..:|::||.|:||.|| |||:||.
Mouse   268 AGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQ-EPIFIVT 331

  Fly   358 EYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKIC 422
            |:|:||||||||:..:|.......||..:.|::.||.::|.:..|||||.|.|:|:..:.|.||.
Mouse   332 EFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIA 396

  Fly   423 DFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHS 487
            ||||||:|.|:||..::|::||:||||||||.:|.|:|||||||:||||||:.|||::|||||.:
Mouse   397 DFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSN 461

  Fly   488 REVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
            .|||..:|.|:|||:|.|  .|:.:|.::::||...||:|||||::....:.|...:|..|::
Mouse   462 PEVIRALEHGYRMPRPDN--CPEELYNIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	24/50 (48%)
		SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		STYKc	285..537	CDD:214568	130/251 (52%)
		PTKc_Src_like	289..538	CDD:270630	129/248 (52%)
Hck	NP_034537.2	SH3	80..135	CDD:302595	27/55 (49%)
		SH2_Src_HCK	138..241	CDD:198226	50/103 (49%)
		PKc_like	252..522	CDD:304357	137/272 (50%)
		Pkinase_Tyr	260..509	CDD:285015	130/251 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6752
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820