DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Grb2

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001300865.1	Gene:	Grb2 / 14784	MGIID:	95805	Length:	217	Species:	Mus musculus

Alignment Length:	183	Identity:	52/183 - (28%)
Similarity:	92/183 - (50%)	Gaps:	26/183 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVI-DDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFF 164
            :|.||:|:..:.:|||.:||.::|: ::.:.:|::..  ...::|.||.|::    .:....|||
Mouse     4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAE--LNGKDGFIPKNYI----EMKPHPWFF 62

  Fly   165 ENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIA 229
            ..:.|.:|:: :|:::...|.||:|.||..|..:|||||...|     |:|:::. .|..|.|..
Mouse    63 GKIPRAKAEE-MLSKQRHDGAFLIRESESAPGDFSLSVKFGND-----VQHFKVL-RDGAGKYFL 120

  Fly   230 TNQTFPSLQALV-----MAYSKENALGLCHILSRPCPKPQP----QMWDLGPE 273
            ....|.||..||     .:.|:...:.|..|...|   .||    .::|..|:
Mouse   121 WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMP---QQPTYVQALFDFDPQ 170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/49 (29%)
		SH2_Src_family	158..259	CDD:199827	32/105 (30%)
		STYKc	285..537	CDD:214568
		PTKc_Src_like	289..538	CDD:270630
Grb2	NP_001300865.1	SH3_GRB2_N	1..56	CDD:212879	15/57 (26%)
		SH2_Grb2_like	56..150	CDD:199828	31/100 (31%)
		SH3_GRB2_C	160..212	CDD:212882	2/11 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910