DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Fyn

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_030100741.1	Gene:	Fyn / 14360	MGIID:	95602	Length:	576	Species:	Mus musculus

Alignment Length:	574	Identity:	272/574 - (47%)
Similarity:	371/574 - (64%)	Gaps:	57/574 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GGYKKSDYTFGQTHINSSG----GGNMGG-VLG-----------QKHNNGGSLDS----RYTPD- 64
            ||..:||..| :.|:....    |||:|. ::|           ......|||:.    ||..|
Mouse    10 GGKSQSDRWF-RRHVVYIKFVIVGGNLGAWIMGCVQCKDKEAAKLTEERDGSLNQSSGYRYGTDP 73

  Fly    65 -------------PNHRGPLKIGGK-----GGVD------IIRPRTTPTGVPGVVLKRVVVALYD 105
                         ||:......||:     |||:      .:|.|    |..||.|   .|||||
Mouse    74 TPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTR----GGTGVTL---FVALYD 131

  Fly   106 YKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRK 170
            |::|.|.||||.||::.::::.:|.|||...:|||.:.|.||.|:||...|:.:|:|:|..:.||
Mouse   132 YEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRK 196

  Fly   171 EADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFP 235
            :|::.||:..|||||||:|.||.....||||::||:|.:|.|||||:|:.||||||||.|...|.
Mouse   197 DAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFE 261

  Fly   236 SLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVF 300
            :||.||..|| |.|.|||..|..||.|..|::.||..:.:|.:||||..:||:::||.|.||||:
Mouse   262 TLQQLVQHYS-ERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVW 325

  Fly   301 YGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSL 365
            .|.|..:..||:|||:.||||..:||:||.||||.:|::||.||||.| |||||||.||||||||
Mouse   326 MGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMSKGSL 389

  Fly   366 LDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVI 430
            ||||::|:||.|...:|:.:|.|||:||.|:|....|||||.:.|:|:|...:.||.||||||:|
Mouse   390 LDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 454

  Fly   431 ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIE 495
            .|:||..:||::||:|||||||.:||:|:|||||||:||||.||.|.|:||||||::|||:|.:|
Mouse   455 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE 519

  Fly   496 RGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            ||:|||.|.:  .|.::::|::.||...||:|||||:|..:.|.:...:|..|:
Mouse   520 RGYRMPCPQD--CPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	24/50 (48%)
		SH2_Src_family	158..259	CDD:199827	54/100 (54%)
		STYKc	285..537	CDD:214568	146/251 (58%)
		PTKc_Src_like	289..538	CDD:270630	144/248 (58%)
Fyn	XP_030100741.1	SH3_Fyn_Yrk	124..179	CDD:212939	27/57 (47%)
		SH2_Src_Fyn_isoform_a_like	184..284	CDD:198281	54/100 (54%)
		PTKc_Fyn	300..573	CDD:270655	154/275 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6752
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.780