DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and Frk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001153016.1	Gene:	Frk / 14302	MGIID:	103265	Length:	512	Species:	Mus musculus

Alignment Length:	462	Identity:	221/462 - (47%)
Similarity:	301/462 - (65%)	Gaps:	26/462 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGL-------IPLNFVAEERSVN 158
            |||:||::|...||||..||:::|:|.:...||...:|..:..||       ||.|:|||:||:.
Mouse    55 VALFDYQARTAEDLSFRAGDKLQVLDTSHEGWWLARHLEKKGTGLGQQLQGYIPSNYVAEDRSLQ 119

  Fly   159 SEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDN 223
            :|.|||..:.|.:|:|.||..||..|.||:|.||.....:||||.|  :|   .||||||:.||.
Mouse   120 AEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLD--EG---VVKHYRIRRLDE 179

  Fly   224 GGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQ-PQMWDLGPELRDKYEIPRSEIQL 287
            ||:::...:.|.:|...|..|:..:. |||..|.:||.|.| |..:||..:..|::||.|:.|||
Mouse   180 GGFFLTRRKVFSTLNEFVNYYTTTSD-GLCVKLEKPCLKIQVPTPFDLSYKTADQWEIDRNSIQL 243

  Fly   288 LRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEP 352
            |::||.|.||||:.|.|.|:..||||||:.|:|....||:||.|||..||.:|:.|||||:.|:|
Mouse   244 LKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDP 308

  Fly   353 IYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENN 417
            |||:.|.|..|||.::|:...|..:|....:.:|.||||||.||||:..|||||||||||:||:|
Mouse   309 IYIITELMRHGSLQEYLQNDGGSKIHLIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHN 373

  Fly   418 VAKICDFGLARVIA---DDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQ 479
            :.|:.|||||||..   :|.|..|...:.||||||||||...||||||||||:||||.|:.|||:
Mouse   374 IYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGK 438

  Fly   480 VPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLN----HYFE-- 538
            :||.||...:||:.:.:.:|:|:|:|  .|...|.::|:||:..|::|||||.|:    .|||
Mouse   439 MPYSGMTGAQVIQMLSQNYRLPQPSN--CPQQFYSIMLECWNVEPKQRPTFETLHWKLEDYFETD 501

  Fly   539 -SFSVTS 544
             |:|.|:
Mouse   502 CSYSDTN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	21/55 (38%)
		SH2_Src_family	158..259	CDD:199827	41/100 (41%)
		STYKc	285..537	CDD:214568	136/258 (53%)
		PTKc_Src_like	289..538	CDD:270630	133/255 (52%)
Frk	NP_001153016.1	SH3_Src_like	54..111	CDD:212779	21/55 (38%)
		SH2_Src_Frk	119..214	CDD:199831	41/100 (41%)
		PTKc_Frk_like	232..501	CDD:270653	143/270 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.770