DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Csk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001291690.1	Gene:	Csk / 12988	MGIID:	88537	Length:	450	Species:	Mus musculus

Alignment Length:	458	Identity:	169/458 - (36%)
Similarity:	253/458 - (55%)	Gaps:	53/458 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDT-ESDWWRVVNLTTRQEGLIPLNFVAEERSVNS----- 159
            :|.|::....|.||.|.|||.:.::..| :.:|::..|...| ||:||.|:|.:...|.:
Mouse    15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKREGVKAGTKLS 78

  Fly   160 -EDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIK---- 219
             ..||...:.|::|::||...|.  |.||||.|.:.|..|:|.|..  :|:   |:||||.
Mouse    79 LMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSC--EGK---VEHYRIMYHAS 136

  Fly   220 --PLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRP-----CPKPQPQMWDLGPELRDK 277
              .:|...|       |.:|..||..|:.: |.|||..|.:|     ....|.:.:      |..
Mouse   137 KLSIDEEVY-------FENLMQLVEHYTTD-ADGLCTRLIKPKVMEGTVAAQDEFY------RSG 187

  Fly   278 YEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVA 342
            :.:...|::||:.:|:|.||:|..|.:|.: .||||.::... :..|||.||::|.:.||:.||.
Mouse   188 WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDA-TAQAFLAEASVMTQLRHSNLVQ 250

  Fly   343 LYAVCSQEE-PIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDL 406
            |..|..:|: .:|||.|||:||||:|:||......|..:.|:..:..|...|||||....:||||
Mouse   251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315

  Fly   407 AARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILL 471
            ||||||:.|:||||:.||||.:..:..:    ...:.|||||||||:...|||.||||||:||||
Mouse   316 AARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAPEALREKKFSTKSDVWSFGILL 376

  Fly   472 MELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF----EF 532
            .|::::|:||||.:..::|:..:|:|::|..|..  .|..:|:::..||......||||    |.
Mouse   377 WEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDG--CPPAVYEVMKNCWHLDAATRPTFLQLREQ 439

  Fly   533 LNH 535
            |.|
Mouse   440 LEH 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	17/49 (35%)
		SH2_Src_family	158..259	CDD:199827	35/112 (31%)
		STYKc	285..537	CDD:214568	110/256 (43%)
		PTKc_Src_like	289..538	CDD:270630	108/252 (43%)
Csk	NP_001291690.1	Interaction with PTPN22. /evidence=ECO:0000269\|PubMed:8890164	9..70		19/55 (35%)
		SH3_CSK	11..67	CDD:212703	19/52 (37%)
		SH2_csk_like	78..175	CDD:198190	36/111 (32%)
		PTKc_Csk	188..443	CDD:133213	111/263 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810