DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Btk

DIOPT Version :9

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_038510.2 Gene:Btk / 12229 MGIID:88216 Length:659 Species:Mus musculus


Alignment Length:498 Identity:184/498 - (36%)
Similarity:282/498 - (56%) Gaps:36/498 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 NNGGSLDSRYTPDPNHR---GPL-------KIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDY 106
            |..|||    .|..:||   .||       :|..|.    :.|..|...:....||: |||||||
Mouse   170 NRNGSL----KPGSSHRKTKKPLPPTPEEDQILKKP----LPPEPTAAPISTTELKK-VVALYDY 225

  Fly   107 KSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAE-ERSVNSEDWFFENVLRK 170
            ...:.:||...||:...:::::...|||..: ...|||.||.|::.| |.|:...:|:.:::.|.
Mouse   226 MPMNANDLQLRKGEEYFILEESNLPWWRARD-KNGQEGYIPSNYITEAEDSIEMYEWYSKHMTRS 289

  Fly   171 EADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHVKHYRIKPLDNGGYYIATNQT 233
            :|:: ||.:|...|.|:||.|. ....|::||  |...:.:|. ::||.:.......||:|....
Mouse   290 QAEQ-LLKQEGKEGGFIVRDSS-KAGKYTVSVFAKSTGEPQGV-IRHYVVCSTPQSQYYLAEKHL 351

  Fly   234 FPSLQALVMAYSKENALGLCHILSRPCPKPQ---PQMWDLGPELRDKYEIPRSEIQLLRKLGRGN 295
            |.::..|: .|.:.|:.||...|..|..|..   |....||   ...:||...::..|::||.|.
Mouse   352 FSTIPELI-NYHQHNSAGLISRLKYPVSKQNKNAPSTAGLG---YGSWEIDPKDLTFLKELGTGQ 412

  Fly   296 FGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYM 360
            ||.|.|||||...|||:|.:|||:||...|::||.:|....|.:||.||.||:::.||:|:.|||
Mouse   413 FGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYM 477

  Fly   361 SKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFG 425
            :.|.||::|||...|: ..:.|:.:...|...||||||||.:||||||||.|:.:..|.|:.|||
Mouse   478 ANGCLLNYLREMRHRF-QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFG 541

  Fly   426 LARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREV 490
            |:|.:.||||....||:|||:|:.||.::|.|||.|||:|::|:|:.|:::.|::||....:.|.
Mouse   542 LSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSET 606

  Fly   491 IENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
            .|:|.:|.|:.:|  |...:.:|.::..||....::||:|:.|
Mouse   607 AEHIAQGLRLYRP--HLASERVYTIMYSCWHEKADERPSFKIL 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH3_Src_like 99..150 CDD:212779 19/50 (38%)
SH2_Src_family 158..259 CDD:199827 28/102 (27%)
STYKc 285..537 CDD:214568 111/249 (45%)
PTKc_Src_like 289..538 CDD:270630 110/245 (45%)
BtkNP_038510.2 PH_Btk 6..166 CDD:269944
Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250 12..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 171..210 12/46 (26%)
SH3_BTK 217..271 CDD:212839 21/55 (38%)
SH2_Tec_Btk 274..378 CDD:198260 30/107 (28%)
PTKc_Btk_Bmx 397..652 CDD:173657 112/254 (44%)
Inhibitor-binding. /evidence=ECO:0000250 474..479 3/4 (75%)
CAV1-binding. /evidence=ECO:0000250 581..588 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.810

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