Protein Alignment Src64B and Bmx

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_033889.2
• Gene: Bmx / 12169
• MGIID: 1101778
• Length: 655
• Species: Mus musculus
• Alignment Length: 528
• Identity: 186/528 - (35%)
• Similarity: 265/528 - (50%)
• Gaps: 74/528 - (14%)

  Fly    64 DPNHRGP------LKIGGKGGVDIIRPRTTPTGVPGVVLKR------VVVALYDYKSRDESDLSF 116
            |..||.|      |||          ||..|      |||.      .::..||..|:.......
Mouse   162 DEKHRAPTFPERLLKI----------PRAVP------VLKMDASSSGAILPQYDSYSKKSCGSQP 210

  Fly   117 MKGDRMEVIDDTESDWWRVVNLTTRQE---------------------GLIPLNFVAEERSVNSE 160
            ....|....:|. .|||:|..|.:.::                     |....:...||.::::.
Mouse   211 TSNIRYIPREDC-PDWWQVRKLKSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAY 274

  Fly   161 DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHVKHYRIKPLDN 223
            |||..|:.|.:::: ||.::...|.|:||.|. ....|::|:  |...|.:| .||||.:.....
Mouse   275 DWFAGNISRSQSEQ-LLRQKGKEGAFMVRNSS-QMGMYTVSLFSKAVNDKKG-TVKHYHVHTNAE 336

  Fly   224 GGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPC---PKPQPQMWDLGPELRDKYEIPRSEI 285
            ...|:|.|..|.|:..|: .|.:.|:.|:...|..|.   ....|....||..:   :|:.|.||
Mouse   337 NKLYLAENYCFDSIPKLI-HYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGI---WELKREEI 397

  Fly   286 QLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE 350
            .||::||.|.||.|..|:|:...|||||.::||.||...|.|||..|.|..|.:||..|.|||::
Mouse   398 TLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKK 462

  Fly   351 EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGE 415
            .|||||.||::.|.||::|: ..|:.|....|:.:...|..||.:|||.|.|||||||||.|:..
Mouse   463 YPIYIVTEYITNGCLLNYLK-SHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDS 526

  Fly   416 NNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQV 480
            :...|:.|||:.|.:.||:|....|::|||||:|||...|.|:|.|||||::|||:.|:|:.|:.
Mouse   527 DLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQ 591

  Fly   481 PYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSE 545
            ||....:.||:..:.:|.|:.:|  ....|.|||::..||..:|||||||:.|....|
Mouse   592 PYDLYDNSEVVVKVSQGHRLYRP--QLASDTIYQIMYSCWHELPEKRPTFQQLLSAIE------- 647

  Fly   546 VPYREVQD 553
             |.|| ||
Mouse   648 -PLRE-QD 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	31/102 (30%)
		PTKc_Src_like	289..538	CDD:270630	113/248 (46%)
		SH3_Src_like	99..150	CDD:212779	11/71 (15%)
Bmx	NP_033889.2	PH_Btk	25..151	CDD:269944
		SH2_Tec_Bmx	269..374	CDD:198262	32/108 (30%)
		Protein Kinases, catalytic domain	392..647	CDD:473864	118/257 (46%)