DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and Bmx

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_033889.2	Gene:	Bmx / 12169	MGIID:	1101778	Length:	655	Species:	Mus musculus

Alignment Length:	528	Identity:	186/528 - (35%)
Similarity:	265/528 - (50%)	Gaps:	74/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 DPNHRGP------LKIGGKGGVDIIRPRTTPTGVPGVVLKR------VVVALYDYKSRDESDLSF 116
            |..||.|      |||          ||..|      |||.      .::..||..|:.......
Mouse   162 DEKHRAPTFPERLLKI----------PRAVP------VLKMDASSSGAILPQYDSYSKKSCGSQP 210

  Fly   117 MKGDRMEVIDDTESDWWRVVNLTTRQE---------------------GLIPLNFVAEERSVNSE 160
            ....|....:|. .|||:|..|.:.::                     |....:...||.::::.
Mouse   211 TSNIRYIPREDC-PDWWQVRKLKSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAY 274

  Fly   161 DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHVKHYRIKPLDN 223
            |||..|:.|.:::: ||.::...|.|:||.|. ....|::|:  |...|.:| .||||.:.....
Mouse   275 DWFAGNISRSQSEQ-LLRQKGKEGAFMVRNSS-QMGMYTVSLFSKAVNDKKG-TVKHYHVHTNAE 336

  Fly   224 GGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPC---PKPQPQMWDLGPELRDKYEIPRSEI 285
            ...|:|.|..|.|:..|: .|.:.|:.|:...|..|.   ....|....||..:   :|:.|.||
Mouse   337 NKLYLAENYCFDSIPKLI-HYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGI---WELKREEI 397

  Fly   286 QLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE 350
            .||::||.|.||.|..|:|:...|||||.::||.||...|.|||..|.|..|.:||..|.|||::
Mouse   398 TLLKELGNGQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKK 462

  Fly   351 EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGE 415
            .|||||.||::.|.||::|: ..|:.|....|:.:...|..||.:|||.|.|||||||||.|:..
Mouse   463 YPIYIVTEYITNGCLLNYLK-SHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDS 526

  Fly   416 NNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQV 480
            :...|:.|||:.|.:.||:|....|::|||||:|||...|.|:|.|||||::|||:.|:|:.|:.
Mouse   527 DLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQ 591

  Fly   481 PYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSE 545
            ||....:.||:..:.:|.|:.:|  ....|.|||::..||..:|||||||:.|....|
Mouse   592 PYDLYDNSEVVVKVSQGHRLYRP--QLASDTIYQIMYSCWHELPEKRPTFQQLLSAIE------- 647

  Fly   546 VPYREVQD 553
             |.|| ||
Mouse   648 -PLRE-QD 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	11/71 (15%)
		SH2_Src_family	158..259	CDD:199827	31/102 (30%)
		STYKc	285..537	CDD:214568	116/251 (46%)
		PTKc_Src_like	289..538	CDD:270630	113/248 (46%)
Bmx	NP_033889.2	PH_Btk	25..151	CDD:269944
		PH	27..115	CDD:278594
		SH2_Tec_Bmx	269..374	CDD:198262	32/108 (30%)
		PKc_like	392..647	CDD:304357	118/257 (46%)
		Pkinase_Tyr	397..646	CDD:285015	116/251 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810