DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Abl2

DIOPT Version :10

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_033725.2 Gene:Abl2 / 11352 MGIID:87860 Length:1182 Species:Mus musculus


Alignment Length:452 Identity:190/452 - (42%)
Similarity:276/452 - (61%) Gaps:18/452 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFE 165
            |||||:.:..::.||..||:::.|:...::..|..|. :...:|.:|.|::....|:....|:..
Mouse   113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKHSWYHG 176

  Fly   166 NVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIAT 230
            .|.|..|:.||.:..|  |:||||.||.:|...|:|::  .:||.|   ||||....:...|:..
Mouse   177 PVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR--YEGRVY---HYRINTTTDSKVYVTA 234

  Fly   231 NQTFPSLQALVMAYSKENALGLCHILSRPCPK-PQPQMWDLGPELRDKYEIPRSEIQLLRKLGRG 294
            ...|.:|..||..:|.. |.||...|..|.|| .:|.::.:.| :.||:|:.|::|.:..|||.|
Mouse   235 ESRFSTLAELVHHHSTV-ADGLVTTLHYPAPKCNKPTVYGVSP-IHDKWEMERTDITMKHKLGGG 297

  Fly   295 NFGEVFYGKWRN-SIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQE 358
            .:|||:.|.|:. |:.||||||:|.||....||:|||:||:.:|..||.|..||:.|.|.|||.|
Mouse   298 QYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 362

  Fly   359 YMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICD 423
            ||..|:|||:|||.....:....|:|:|||::|.|||||.|..|||||||||.|:|||:|.|:.|
Mouse   363 YMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 427

  Fly   424 FGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSR 488
            |||:|::..|.|....|::||:||||||::.|..||||||||::|:||.|:.|||..||||:...
Mouse   428 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 492

  Fly   489 EVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESF----SVTSEV 546
            :|.:.:|:|:||.:|..  .|..:|:|:..||...|..||:|...:..||:.    |::.||
Mouse   493 QVYDLLEKGYRMEQPEG--CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH2_Src_family 158..259 CDD:199827 34/100 (34%)
PTKc_Src_like 289..538 CDD:270630 125/249 (50%)
SH3_Src_like 99..150 CDD:212779 14/48 (29%)
Abl2NP_033725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
CAP 2..106
SH3_Abl 111..164 CDD:212784 15/51 (29%)
SH2_ABL 169..262 CDD:198189 34/100 (34%)
PTKc_Abl 281..543 CDD:270645 130/263 (49%)
Kinase activation loop. /evidence=ECO:0000250 427..451 10/23 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..642
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674
Nuclear localization signal. /evidence=ECO:0000255 659..661
F-actin-binding 695..930
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 765..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..858
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1059
F-actin-binding 1020..1182
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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