Protein Alignment Src64B and Abl2

DIOPT Version :9

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_033725.2
• Gene: Abl2 / 11352
• MGIID: 87860
• Length: 1182
• Species: Mus musculus
• Alignment Length: 452
• Identity: 190/452 - (42%)
• Similarity: 276/452 - (61%)
• Gaps: 18/452 - (3%)

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFE 165
            |||||:.:..::.||..||:::.|:...::..|..|. :...:|.:|.|::....|:....|:..
Mouse   113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR-SKNGQGWVPSNYITPVNSLEKHSWYHG 176

  Fly   166 NVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIAT 230
            .|.|..|:.||.:..|  |:||||.||.:|...|:|::  .:||.|   ||||....:...|:..
Mouse   177 PVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR--YEGRVY---HYRINTTTDSKVYVTA 234

  Fly   231 NQTFPSLQALVMAYSKENALGLCHILSRPCPK-PQPQMWDLGPELRDKYEIPRSEIQLLRKLGRG 294
            ...|.:|..||..:|.. |.||...|..|.|| .:|.::.:.| :.||:|:.|::|.:..|||.|
Mouse   235 ESRFSTLAELVHHHSTV-ADGLVTTLHYPAPKCNKPTVYGVSP-IHDKWEMERTDITMKHKLGGG 297

  Fly   295 NFGEVFYGKWRN-SIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQE 358
            .:|||:.|.|:. |:.||||||:|.||....||:|||:||:.:|..||.|..||:.|.|.|||.|
Mouse   298 QYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTE 362

  Fly   359 YMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICD 423
            ||..|:|||:|||.....:....|:|:|||::|.|||||.|..|||||||||.|:|||:|.|:.|
Mouse   363 YMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 427

  Fly   424 FGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSR 488
            |||:|::..|.|....|::||:||||||::.|..||||||||::|:||.|:.|||..||||:...
Mouse   428 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS 492

  Fly   489 EVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESF----SVTSEV 546
            :|.:.:|:|:||.:|..  .|..:|:|:..||...|..||:|...:..||:.    |::.||
Mouse   493 QVYDLLEKGYRMEQPEG--CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEV 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/48 (29%)
		SH2_Src_family	158..259	CDD:199827	34/100 (34%)
		STYKc	285..537	CDD:214568	126/252 (50%)
		PTKc_Src_like	289..538	CDD:270630	125/249 (50%)
Abl2	NP_033725.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42
		CAP	2..106
		SH3_Abl	111..164	CDD:212784	15/51 (29%)
		SH2_ABL	169..262	CDD:198189	34/100 (34%)
		PTKc_Abl	281..543	CDD:270645	130/263 (49%)
		STYKc	288..539	CDD:214568	126/252 (50%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		10/23 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	612..642
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..674
		Nuclear localization signal. /evidence=ECO:0000255	659..661
		F-actin-binding	695..930
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	765..796
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	809..858
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1059
		F-actin-binding	1020..1182
		FABD	1063..1182	CDD:197885

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910