DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and GRAP

DIOPT Version :9

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_006604.1 Gene:GRAP / 10750 HGNCID:4562 Length:217 Species:Homo sapiens


Alignment Length:228 Identity:55/228 - (24%)
Similarity:98/228 - (42%) Gaps:60/228 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 VALYDYKSRDESDLSFMKGDRMEVID-DTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFF 164
            ||||.:::.:..:|:|.|||.::::: :.:.:|::..  ....||.||.|::    .|....|:.
Human     4 VALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAE--LRGVEGFIPKNYI----RV
KPHPWYS 62

  Fly   165 ENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIA 229
            ..:.|:.|:::|: :.|..|.||:|.||.:|..:|:||     ..|..|:|:::....:|.|:: 
Human    63 GRISRQLAEEILM-KRNHLGAFLIRESESSPGEFSVSV-----NYGDQVQHFKVLREASGKYFL- 120

  Fly   230 TNQTFPSLQALVMAY-----SKENAL------------GLC------------------------ 253
            ..:.|.||..||..|     :|:..:            |.|                        
Human   121 WEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDII 185

  Fly   254 HILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQ 286
            .:|.||.|.     |..|.........|||.:|
Human   186 EVLERPDPH-----WWRGRSCGRVGFFPRSYVQ 213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH3_Src_like 99..150 CDD:212779 14/49 (29%)
SH2_Src_family 158..259 CDD:199827 30/141 (21%)
STYKc 285..537 CDD:214568 1/2 (50%)
PTKc_Src_like 289..538 CDD:270630
GRAPNP_006604.1 SH3_GRAP_N 2..55 CDD:212881 15/56 (27%)
SH2_Grb2_like 56..150 CDD:199828 27/100 (27%)
SH3_GRAP_C 162..214 CDD:212884 10/57 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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