Protein Alignment Src64B and hck

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_005174178.1
• Gene: hck / 101885596
• ZFINID: ZDB-GENE-090313-72
• Length: 499
• Species: Danio rerio
• Alignment Length: 519
• Identity: 233/519 - (44%)
• Similarity: 332/519 - (63%)
• Gaps: 36/519 - (6%)

  Fly    45 GVLGQKHNN---GGSLDS-------RYTPDPNHRGPLKIGGKGGVDIIRPRTTPTG-VPGV-VLK 97
            |.:|.|...   |.|::|       .||.||.      .|.|..      |||... .||. ..:
Zfish     2 GCVGTKPEQDPIGKSVNSDDNRNVAHYTKDPT------TGAKAN------RTTSNAQTPGTDTSE 54

  Fly    98 RVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDW 162
            .:.:|||||::..|.||.|.||||:.::.:: .:||:.|.::|.|||.||.|:||:: ::.:|:|
Zfish    55 NIAIALYDYEAMHEGDLGFKKGDRLRILQES-GEWWKAVIISTGQEGFIPSNYVAKD-TLETEEW 117

  Fly   163 FFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYY 227
            ||:.|.||:|::.|||..|..|:|::|.||.....|||||:| .|.:...||||:|:.|||||:|
Zfish   118 FFKGVSRKDAERQLLASGNKTGSFMIRDSETTKGSYSLSVRD-SDHQADTVKHYKIRTLDNGGFY 181

  Fly   228 IATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKL 291
            |:...||.:||.||..|.|::. |||..|:.||..|:||. |:     :|.:||||..::|.::|
Zfish   182 ISPRITFNTLQDLVSHYKKQSD-GLCQSLTSPCLSPKPQKPWE-----KDAWEIPRESLKLDKRL 240

  Fly   292 GRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIV 356
            |.|.||||:...:.....|||||::.|:||..|||.||.:||..:|::||.|.||.::||||||:
Zfish   241 GAGQFGEVWMAMYNKHTKVAVKTMKPGSMSVEAFLMEANLMKSLQHDKLVRLNAVVTKEEPIYII 305

  Fly   357 QEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKI 421
            .|:|.|||||||::..:|..:....||..:.|:|.||.|:|.:..|||||.|.|:|:.::.|.||
Zfish   306 TEFMEKGSLLDFIKSDEGNRVQLPKLIDFSAQIAEGMAYIEQRNYIHRDLRAANILVNKSLVCKI 370

  Fly   422 CDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMH 486
            .||||||:|.|:||..::|::||:||||||||.||.|:|||||||:||||.|:.:||:.|||||.
Zfish   371 ADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIISYGRTPYPGMT 435

  Fly   487 SREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
            :.|||..:|||:||.:..:  .|..:|.::|:||...||.|||||:|....|.|...:|..|::
Zfish   436 NPEVIRALERGYRMQRLDS--CPQELYDIMLECWKNKPEDRPTFEYLQSVLEDFYTATESQYQQ 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		PTKc_Src_like	289..538	CDD:270630	127/248 (51%)
		SH3_Src_like	99..150	CDD:212779	22/50 (44%)
hck	XP_005174178.1	SH3	58..109	CDD:473055	24/51 (47%)
		SH2	113..215	CDD:472789	50/103 (49%)
		PTKc_Hck	222..487	CDD:270658	135/271 (50%)