DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and hck

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_005174178.1	Gene:	hck / 101885596	ZFINID:	ZDB-GENE-090313-72	Length:	499	Species:	Danio rerio

Alignment Length:	519	Identity:	233/519 - (44%)
Similarity:	332/519 - (63%)	Gaps:	36/519 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GVLGQKHNN---GGSLDS-------RYTPDPNHRGPLKIGGKGGVDIIRPRTTPTG-VPGV-VLK 97
            |.:|.|...   |.|::|       .||.||.      .|.|..      |||... .||. ..:
Zfish     2 GCVGTKPEQDPIGKSVNSDDNRNVAHYTKDPT------TGAKAN------RTTSNAQTPGTDTSE 54

  Fly    98 RVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDW 162
            .:.:|||||::..|.||.|.||||:.::.:: .:||:.|.::|.|||.||.|:||:: ::.:|:|
Zfish    55 NIAIALYDYEAMHEGDLGFKKGDRLRILQES-GEWWKAVIISTGQEGFIPSNYVAKD-TLETEEW 117

  Fly   163 FFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYY 227
            ||:.|.||:|::.|||..|..|:|::|.||.....|||||:| .|.:...||||:|:.|||||:|
Zfish   118 FFKGVSRKDAERQLLASGNKTGSFMIRDSETTKGSYSLSVRD-SDHQADTVKHYKIRTLDNGGFY 181

  Fly   228 IATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKL 291
            |:...||.:||.||..|.|::. |||..|:.||..|:||. |:     :|.:||||..::|.::|
Zfish   182 ISPRITFNTLQDLVSHYKKQSD-GLCQSLTSPCLSPKPQKPWE-----KDAWEIPRESLKLDKRL 240

  Fly   292 GRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIV 356
            |.|.||||:...:.....|||||::.|:||..|||.||.:||..:|::||.|.||.::||||||:
Zfish   241 GAGQFGEVWMAMYNKHTKVAVKTMKPGSMSVEAFLMEANLMKSLQHDKLVRLNAVVTKEEPIYII 305

  Fly   357 QEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKI 421
            .|:|.|||||||::..:|..:....||..:.|:|.||.|:|.:..|||||.|.|:|:.::.|.||
Zfish   306 TEFMEKGSLLDFIKSDEGNRVQLPKLIDFSAQIAEGMAYIEQRNYIHRDLRAANILVNKSLVCKI 370

  Fly   422 CDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMH 486
            .||||||:|.|:||..::|::||:||||||||.||.|:|||||||:||||.|:.:||:.|||||.
Zfish   371 ADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIISYGRTPYPGMT 435

  Fly   487 SREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
            :.|||..:|||:||.:..:  .|..:|.::|:||...||.|||||:|....|.|...:|..|::
Zfish   436 NPEVIRALERGYRMQRLDS--CPQELYDIMLECWKNKPEDRPTFEYLQSVLEDFYTATESQYQQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	22/50 (44%)
		SH2_Src_family	158..259	CDD:199827	48/100 (48%)
		STYKc	285..537	CDD:214568	128/251 (51%)
		PTKc_Src_like	289..538	CDD:270630	127/248 (51%)
hck	XP_005174178.1	SH3	58..109	CDD:302595	24/51 (47%)
		SH2	113..215	CDD:301589	50/103 (49%)
		PTKc_Hck	222..487	CDD:270658	135/271 (50%)
		Pkinase_Tyr	234..484	CDD:285015	128/251 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100661
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820