DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and fgr

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_002934688.1	Gene:	fgr / 100493811	XenbaseID:	XB-GENE-6073541	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	253/507 - (49%)
Similarity:	345/507 - (68%)	Gaps:	19/507 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NGGSLDSRYTPDPNHRGPLKI---------GGKGGVDI-IRPRTTPTGVPGVVLKRVVVALYDYK 107
            |...:..||.|||..:.|.:|         .|.|||.. ...|....||.|.|.:  .:|||||.
Frog    17 NALEIPQRYCPDPTSQMPFRIQETHTPFISAGIGGVIAGSSQRGMGVGVTGGVTQ--FIALYDYD 79

  Fly   108 SRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEA 172
            :|.|.||:|.||::..:|:::|.|||...:|::...|.||.|:||...|:.|:||:|..:.||:|
Frog    80 ARTEDDLTFKKGEKFHIINNSEGDWWEARSLSSGNTGYIPSNYVAPMNSIQSKDWYFGKIGRKDA 144

  Fly   173 DKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSL 237
            ::|||.|.||||||::|.||.....|||||:||:..||.|.|||:|:.|||||:||.|...|.::
Frog   145 ERLLLCEGNPRGTFMIRESETTKGAYSLSVRDWDATRGDHAKHYKIRKLDNGGFYITTRVQFDTV 209

  Fly   238 QALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYG 302
            :.||..||:.|. ||||:|:.||...:||...|.   :|.:||.|..|.|.:|||:|.||:|:.|
Frog   210 EELVEHYSEFND-GLCHLLTNPCINQKPQTLGLS---KDAWEITRDSISLDKKLGQGCFGDVWKG 270

  Fly   303 KWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLD 367
            .|..:.:||||||:..|||..|||:||.||||.||::||.||||.| |||||||.|:|:||||||
Frog   271 TWNGTTNVAVKTLKPSTMSPEAFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEFMTKGSLLD 334

  Fly   368 FLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIAD 432
            :|:||:|..|....|:.::.|:||||.|:|....|||||.|.|:|:|:|.:.||.||||||:|.|
Frog   335 YLKEGEGHLLKLPQLVDMSGQIASGMAYIERMNYIHRDLRAANILVGDNLICKIADFGLARLIED 399

  Fly   433 DEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERG 497
            :||..:||::||:|||||||.:||||:|||||||:||::.||.|.|::|||||.:|||:|.:|||
Frog   400 NEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGIMVCELVTKGRIPYPGMSNREVLEQVERG 464

  Fly   498 FRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            :|||.|.  ..|.::::|:||||...||:|||||:|..:.|.:...:|..|:
Frog   465 YRMPAPP--ACPPSLHELMLQCWRGDPEERPTFEYLQSFLEDYFTATEPQYQ 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	21/50 (42%)
		SH2_Src_family	158..259	CDD:199827	53/100 (53%)
		STYKc	285..537	CDD:214568	146/251 (58%)
		PTKc_Src_like	289..538	CDD:270630	144/248 (58%)
fgr	XP_002934688.1	SH3	72..125	CDD:388381	23/52 (44%)
		SH2_Src_Fgr	130..230	CDD:198230	53/100 (53%)
		PTKc_Src_Fyn_like	257..504	CDD:271105	144/249 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6746
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110