DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and ptk6

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_002942429.3	Gene:	ptk6 / 100490792	XenbaseID:	XB-GENE-22069031	Length:	563	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	218/566 - (38%)
Similarity:	306/566 - (54%)	Gaps:	55/566 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QELALAYPTGGYKKSDY----TFGQTHINSSG---GGNMGGVLGQKHNNGGSLDSRYTPDPNHRG 69
            |::.|:...||......    :...|..:|:.   |.|   ||.|.|..        :|.|..:|
Frog    18 QQVGLSRSLGGKAPQSLHCSASLTSTFFSSNALRVGAN---VLTQSHFR--------SPCPLLQG 71

  Fly    70 PLKIGGKGGVDIIRPRTTPTGVPGVVL----------KRVVVALYDYKSRDESDLSFMKGDRMEV 124
            ..:...|       |.|.....||..|          || .|:|:|:|:....:|||..||..||
Frog    72 RQRWDEK-------PETLALIFPGNWLDGNAKMSHRPKR-FVSLWDFKAEAPEELSFKVGDVFEV 128

  Fly   125 IDDTESDWWRVVNLT-----TRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRG 184
            : |...|||.|..|.     ..:.|.:|.||:|||.:|..::|||....|.||..||:.|.|..|
Frog   129 L-DRSGDWWHVQKLKGDGKGKPEVGYVPYNFLAEEGTVEEQEWFFGEKSRTEAVNLLMDEGNTNG 192

  Fly   185 TFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENA 249
            :||:|.|:.:...|.|||:..:..|     |::|.....|.:::.....||.|:.||..|.|:..
Frog   193 SFLIRASDKHGILYVLSVRHQDSTR-----HFKIMRNPEGQFHLNNMTFFPDLKQLVETYCKKPI 252

  Fly   250 L-GLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVK 313
            . ||  .|::||.|.:|.:.||.|...|::|.||.|..|:::||.||||:|..|.|:..:.||||
Frog   253 CPGL--TLTKPCVKNEPVVSDLSPVPLDEWERPREEFTLVKRLGMGNFGQVHEGLWKGKLKVAVK 315

  Fly   314 TLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLH 378
            |::....|...|::|.|.:|...|..|::||||||..:|.|||.|.:.:|.||::||:.:...|.
Frog   316 TIKRDATSQDLFVKETAFLKTLHHKNLLSLYAVCSVGDPYYIVTELVPRGDLLNYLRDLEKDELD 380

  Fly   379 FEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRF 443
            .|..:.||||||.||.||||:..|||||||||||:|.||:.||.|||:||||.|..|. ......
Frog   381 VEGQLDIATQVAEGMRYLESQNCIHRDLAARNVLMGRNNICKIADFGMARVILDSYYV-SASKEI 444

  Fly   444 PVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYF 508
            |.|||||||:.||::::||||||:||||.|:.:.|..|||.:.:.||:|.:.||.||..|.:  .
Frog   445 PFKWTAPEAVEYGRYTVKSDVWSFGILLYEIMSLGMQPYPALSNYEVLEFLNRGQRMKAPPS--C 507

  Fly   509 PDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFS--VTSEVPYREVQ 552
            ...:|.::|.||...|.:||:|:.|....|:.|  ..|||..:.:|
Frog   508 STRVYNIMLTCWAWNPNERPSFDDLRTMLENLSNYEGSEVAPKPLQ 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	19/55 (35%)
		SH2_Src_family	158..259	CDD:199827	33/101 (33%)
		STYKc	285..537	CDD:214568	119/251 (47%)
		PTKc_Src_like	289..538	CDD:270630	118/248 (48%)
ptk6	XP_002942429.3	SH3	104..161	CDD:418401	21/57 (37%)
		SH2	168..252	CDD:214585	30/88 (34%)
		STYKc	288..536	CDD:214568	119/250 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920