DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src64B and fyn

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_004914619.2	Gene:	fyn / 100488004	XenbaseID:	XB-GENE-6053489	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	256/521 - (49%)
Similarity:	349/521 - (66%)	Gaps:	39/521 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FGQTHINSSGGGNM-GGVLGQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPG 93
            :...|.|:..|..: |||      |..|          |.|.|:..|..||.:.
Frog    50 YNNFHTNAGQGLTVFGGV------NSSS----------HTGTLRTRGGTGVTLF----------- 87

  Fly    94 VVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVN 158
                   ||||||::|.|.||||.||::.::::.:|.|||...:|||...|.||.|:||...|:.
Frog    88 -------VALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQ 145

  Fly   159 SEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDN 223
            :|:|:|..:.||:|::.||:..|||||:|:|.||.....||||::||:|.:|.|||||:|:.|||
Frog   146 AEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDN 210

  Fly   224 GGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLL 288
            |||||.|...|.:||.||..|| |.|.|||..|..||.|..|::.||..:.:|.:||||..:||:
Frog   211 GGYYITTRAQFETLQQLVQHYS-ERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLI 274

  Fly   289 RKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPI 353
            ::||.|.||||:.|.|..:..||:|||:.||||..:||:||.||||.:|::||.||||.| ||||
Frog   275 KRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS-EEPI 338

  Fly   354 YIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNV 418
            |||.||||||||||||::|:||.|...:|:.:|.|||:||.|:|....|||||.:.|:|:|...:
Frog   339 YIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLI 403

  Fly   419 AKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYP 483
            .||.||||||:|.|:||..:||::||:|||||||.:||:|:|||||||:||||.||.|.|:||||
Frog   404 CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP 468

  Fly   484 GMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 548
            ||::|||:|.:|||:|||.|.:  .|:::::|:|.||...||:|||||:|..:.|.:...:|..|
Frog   469 GMNNREVLEQVERGYRMPCPQD--CPNSLHELMLNCWKKDPEERPTFEYLQGFLEDYFTATEPQY 531

  Fly   549 R 549
            :
Frog   532 Q 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	24/50 (48%)
		SH2_Src_family	158..259	CDD:199827	53/100 (53%)
		STYKc	285..537	CDD:214568	147/251 (59%)
		PTKc_Src_like	289..538	CDD:270630	145/248 (58%)
fyn	XP_004914619.2	SH3_Fyn_Yrk	85..140	CDD:212939	26/72 (36%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	53/100 (53%)
		PTKc_Fyn	261..534	CDD:270655	155/275 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6746
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110