Protein Alignment Src64B and Tyk2

DIOPT Version :9

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001244276.1
• Gene: Tyk2 / 100361294
• RGDID: 2320469
• Length: 1186
• Species: Rattus norvegicus
• Alignment Length: 603
• Identity: 158/603 - (26%)
• Similarity: 241/603 - (39%)
• Gaps: 180/603 - (29%)

  Fly    67 HRGPLKIGG--KGGVDIIRPRTTPTGVPG-----------VVLK-------RVVVALYDYKSR-- 109
            :.|.|.:||  :|.||        :|.|.           ||||       .:.:|.|:..|.
  Rat   606 YEGLLSVGGPNEGKVD--------SGCPSGPDRGSGQQLRVVLKVLDPSHHDIALAFYETASLMS 662

  Fly   110 --DESDLSFMKGDRM---------EVIDDTESDWWRVVNLTTRQEGLIPLNF---VAEERS---- 156
              ....|:|:.|..:         |.::....|.|     ..||.|.:|:.:   ||::.:
  Rat   663 QVSHMHLAFLHGVCVRGSENIIVAEFVEHGPLDVW-----LRRQRGRVPMPWKMVVAQQLASALS 722

  Fly   157 -VNSEDWFFENVLRKEADKLLLA----EENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHY 216
             :..::....||..:   .:|||    ||   ||        ||   .:.:.|...|:|...:..
  Rat   723 YLEDKNLVHGNVCGR---NILLARLGLEE---GT--------NP---FIKLSDPGVGQGALSREE 770

  Fly   217 RIKP--------LDNGGYYIATNQTFPSLQALVMA--------------------YSKENAL--G 251
            |::.        |..|...:.|........|.::.                    |:|::.|  .
  Rat   771 RVERIPWTAPECLSGGANSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEP 835

  Fly   252 LC---HILSRPC----PKPQPQMWDLGPELRD---------------KYEIPRSE--------IQ 286
            .|   ..|:|.|    |..:|....:   |||               ..:.|.|:        ::
  Rat   836 SCPELATLTRQCLSYEPAQRPSFRTI---LRDLTRLQPQNLVGTSTVNSDSPASDPTVFHKRYLK 897

  Fly   287 LLRKLGRGNFGEVFYGKWRNSID-----VAVKTLRE--GTMSTAAFLQEAAIMKKFRHNRLVALY 344
            .:|.||.|:||:|....:..:.|     ||||.|:|  |....:.:.:|..|::...|..:|...
  Rat   898 RIRDLGEGHFGKVSLYCYDPNNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYK 962

  Fly   345 AVCSQ--EEPIYIVQEYMSKGSLLDFL-REGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDL 406
            ..|..  |:.:.:|.||:..|||.|:| |...|    ...|:..|.|:..||.||.::..|||||
  Rat   963 GCCEDQGEKSVQLVMEYVPLGSLRDYLPRHSVG----LAQLLLFAQQICEGMAYLHAQHYIHRDL 1023

  Fly   407 AARNVLIGENNVAKICDFGLARVIAD--DEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGI 469
            ||||||:..:.:.||.|||||:.:.:  :.|..::....||.|.|||.:...||...|||||:|:
  Rat  1024 AARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGV 1088

  Fly   470 LLMELFTY-------------------GQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQL 515
            .|.||.||                   ||     |....:.|.:|||.|:|:|..  .|..||.|
  Rat  1089 TLYELLTYCDSSQSPPTKFIELIGVTQGQ-----MTVLRLTELLERGERLPRPDR--CPCEIYHL 1146

  Fly   516 LLQCWDAVPEKRPTFEFL 533
            :..||::....||||:.|
  Rat  1147 MKNCWESEASFRPTFQNL 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	13/63 (21%)
		SH2_Src_family	158..259	CDD:199827	24/137 (18%)
		STYKc	285..537	CDD:214568	97/280 (35%)
		PTKc_Src_like	289..538	CDD:270630	97/276 (35%)
Tyk2	NP_001244276.1	FERM_F1	33..130	CDD:408179
		FERM_F2	148..271	CDD:408177
		Jak1_Phl	290..433	CDD:407742
		SH2	438..536	CDD:417686
		PKc_like	591..866	CDD:419665	59/292 (20%)
		PTKc_Tyk2_rpt2	891..1173	CDD:270664	97/285 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810