DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src64B and Tyk2

DIOPT Version :10

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_001244276.1 Gene:Tyk2 / 100361294 RGDID:2320469 Length:1186 Species:Rattus norvegicus


Alignment Length:603 Identity:158/603 - (26%)
Similarity:241/603 - (39%) Gaps:180/603 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 HRGPLKIGG--KGGVDIIRPRTTPTGVPG-----------VVLK-------RVVVALYDYKSR-- 109
            :.|.|.:||  :|.||        :|.|.           ||||       .:.:|.|:..|.  
  Rat   606 YEGLLSVGGPNEGKVD--------SGCPSGPDRGSGQQLRVVLKVLDPSHHDIALAFYETASLMS 662

  Fly   110 --DESDLSFMKGDRM---------EVIDDTESDWWRVVNLTTRQEGLIPLNF---VAEERS---- 156
              ....|:|:.|..:         |.::....|.|     ..||.|.:|:.:   ||::.:    
  Rat   663 QVSHMHLAFLHGVCVRGSENIIVAEFVEHGPLDVW-----LRRQRGRVPMPWKMVVAQQLASALS 722

  Fly   157 -VNSEDWFFENVLRKEADKLLLA----EENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHY 216
             :..::....||..:   .:|||    ||   ||        ||   .:.:.|...|:|...:..
  Rat   723 YLEDKNLVHGNVCGR---NILLARLGLEE---GT--------NP---FIKLSDPGVGQGALSREE 770

  Fly   217 RIKP--------LDNGGYYIATNQTFPSLQALVMA--------------------YSKENAL--G 251
            |::.        |..|...:.|........|.::.                    |:|::.|  .
  Rat   771 RVERIPWTAPECLSGGANSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEP 835

  Fly   252 LC---HILSRPC----PKPQPQMWDLGPELRD---------------KYEIPRSE--------IQ 286
            .|   ..|:|.|    |..:|....:   |||               ..:.|.|:        ::
  Rat   836 SCPELATLTRQCLSYEPAQRPSFRTI---LRDLTRLQPQNLVGTSTVNSDSPASDPTVFHKRYLK 897

  Fly   287 LLRKLGRGNFGEVFYGKWRNSID-----VAVKTLRE--GTMSTAAFLQEAAIMKKFRHNRLVALY 344
            .:|.||.|:||:|....:..:.|     ||||.|:|  |....:.:.:|..|::...|..:|...
  Rat   898 RIRDLGEGHFGKVSLYCYDPNNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYK 962

  Fly   345 AVCSQ--EEPIYIVQEYMSKGSLLDFL-REGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDL 406
            ..|..  |:.:.:|.||:..|||.|:| |...|    ...|:..|.|:..||.||.::..|||||
  Rat   963 GCCEDQGEKSVQLVMEYVPLGSLRDYLPRHSVG----LAQLLLFAQQICEGMAYLHAQHYIHRDL 1023

  Fly   407 AARNVLIGENNVAKICDFGLARVIAD--DEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGI 469
            ||||||:..:.:.||.|||||:.:.:  :.|..::....||.|.|||.:...||...|||||:|:
  Rat  1024 AARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGV 1088

  Fly   470 LLMELFTY-------------------GQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQL 515
            .|.||.||                   ||     |....:.|.:|||.|:|:|..  .|..||.|
  Rat  1089 TLYELLTYCDSSQSPPTKFIELIGVTQGQ-----MTVLRLTELLERGERLPRPDR--CPCEIYHL 1146

  Fly   516 LLQCWDAVPEKRPTFEFL 533
            :..||::....||||:.|
  Rat  1147 MKNCWESEASFRPTFQNL 1164

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH2_Src_family 158..259 CDD:199827 24/137 (18%)
PTKc_Src_like 289..538 CDD:270630 97/276 (35%)
SH3_Src_like 99..150 CDD:212779 13/63 (21%)
Tyk2NP_001244276.1 FERM_F1 33..130 CDD:465733
FERM_F2 148..271 CDD:436450
Jak1_Phl 290..433 CDD:465552
SH2 438..536 CDD:472789
Protein Kinases, catalytic domain 591..866 CDD:473864 59/292 (20%)
PTKc_Tyk2_rpt2 891..1173 CDD:270664 97/285 (34%)
Blue background indicates that the domain is not in the aligned region.

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