Protein Alignment Src64B and csk

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001135615.1
• Gene: csk / 100216174
• XenbaseID: XB-GENE-5771921
• Length: 450
• Species: Xenopus tropicalis
• Alignment Length: 458
• Identity: 172/458 - (37%)
• Similarity: 254/458 - (55%)
• Gaps: 51/458 - (11%)

  Fly   101 VALYDYKSRDESDLSFMKGDRMEVIDDT-ESDWWRVVNLTTRQEGLIPLNFVAEERSVNS----- 159
            :|.||::.:.|.||.|.||:.:.::..| :.:|::..|...| .|.||.|:|.:...|.|
 Frog    15 IANYDFQGKAEQDLHFSKGEVLTIVAVTKDPNWYKAKNKVGR-VGFIPANYVQKREGVKSGTKLS 78

  Fly   160 -EDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDN 223
             ..||...:.|::|::||...|.  |.||||.|.:.|..|:|.|..  :|:   |:|||| ...:
 Frog    79 LMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSC--EGK---VEHYRI-IYSS 135

  Fly   224 GGYYIATNQTFPSLQALVMAYSKENALGLCHILSRP-----CPKPQPQM----WDLGPELRDKYE 279
            |...|...:.|.:|..||..|:.: |.|||..|.:|     ....|.:.    |.|  ::||
 Frog   136 GKLSIDEEEYFENLMQLVEHYTND-ADGLCTNLMKPKLVEGTVAAQDEFSRSGWAL--KMRD--- 194

  Fly   280 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALY 344
                 ::||..:|:|.||:|..|: ...:.||||.::... :..||:.||.:|.:.:||.||.|.
 Frog   195 -----LKLLHTIGKGEFGDVMLGE-HQGVKVAVKCIKNDA-TAQAFVAEAMVMTQLQHNNLVQLL 252

  Fly   345 AVCSQEEP-IYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAA 408
            .|..:::. ::||.|:|:||||:|:||......|..|.|:..:..|:.||.||||...:||||||
 Frog   253 GVIVEDKSGLFIVTEFMAKGSLVDYLRSRGRSVLGGECLLKFSLDVSEGMAYLESNNFVHRDLAA 317

  Fly   409 RNVLIGENNVAKICDFGL---ARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGIL 470
            ||||:.|.|:||:.||||   |..|.|.       |:.|||||||||:....||.||||||:|||
 Frog   318 RNVLVSEENIAKVSDFGLTKEASAIQDT-------SKLPVKWTAPEALRDKLFSTKSDVWSFGIL 375

  Fly   471 LMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNH 535
            |.|::::|:||||.:..::|:..:|.|::|..|..  .|..:|.|:.|||...|::||||..|..
 Frog   376 LWEIYSFGRVPYPRIALKDVVPKVENGYKMDAPDG--CPPVVYDLMKQCWHLDPKQRPTFRNLRE 438

  Fly   536 YFE 538
            ..|
 Frog   439 QLE 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	36/106 (34%)
		PTKc_Src_like	289..538	CDD:270630	108/252 (43%)
		SH3_Src_like	99..150	CDD:212779	16/49 (33%)
csk	NP_001135615.1	SH3_CSK	11..67	CDD:212703	18/52 (35%)
		SH2_csk_like	78..175	CDD:198190	36/105 (34%)
		Protein Kinases, catalytic domain	188..443	CDD:473864	115/275 (42%)