DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src64B and btk

DIOPT Version :9

Sequence 1:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001123732.1	Gene:	btk / 100170477	XenbaseID:	XB-GENE-6451230	Length:	649	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	192/536 - (35%)
Similarity:	292/536 - (54%)	Gaps:	37/536 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RQDQELALAYPTGGYKKSDY-TFGQTHINSSGG---GNMGGVLGQKHNNGGSLDSRYTPDPNH-R 68
            |.:.::|..|....|:...| ...||..|:.|.   ||..|.:..:.:...|......|.|.. :
Frog   133 RFNSDVAQKYHPRFYQDGQYLCCAQTAKNAMGCQPLGNANGFIRTERSQRRSRKPLPPPPPQESQ 197

  Fly    69 GPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWW 133
            .||               .||  |.:.|.: |||:||:...:..||...||:...::::...:.|
Frog   198 KPL---------------PPT--PCLSLHK-VVAMYDFTPLNAQDLPLHKGEEYVLLEEGTGNPW 244

  Fly   134 RVVNLTTRQEGLIPLNFVAEERS-VNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNG 197
            .........||.||.|:|.|.:. :...:|:.:|:.|.:|:|||.||:. .|.|:||.|. ....
Frog   245 LRARDKNGLEGYIPGNYVTEAQDPLEIYEWYSKNMTRSQAEKLLRAEDK-EGGFIVRDSS-KAGK 307

  Fly   198 YSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRP-CP 261
            |::||.....|.|. ::||.:.......||:|....:.|:..|: .|.:.||.||...|..| |.
Frog   308 YTVSVYAKSSGEGI-IRHYVVCEAPGNQYYLAEKHLYSSIPELI-TYHQHNAAGLISRLKYPVCS 370

  Fly   262 --KPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAA 324
              |..|....||   ...:||...::..|::||.|.||.|.|||||...|||:|.::||:||...
Frog   371 LRKTAPSTAGLG---YGSWEIDPKDLTFLKELGNGQFGVVKYGKWRGQHDVAIKMIKEGSMSEDE 432

  Fly   325 FLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQV 389
            |::||..|.|..|..||.||.||:::.||:|:.|::|.|.||::|::..|| :...||:.:.:.|
Frog   433 FIEEAKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLKDLRGR-VSQGDLLSMCSDV 496

  Fly   390 ASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAII 454
            .:.|.||||||.:||||||||.|:..:.:.|:.||||:|.:.||||....||:|||:|::||.::
Frog   497 CAAMTYLESKQYLHRDLAARNCLVAADGIVKVSDFGLSRYVLDDEYTSSLGSKFPVRWSSPEVLL 561

  Fly   455 YGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQC 519
            |.:||.||||||:|:|:.|:||.|::||....:.|::|.|.||.|:.:|.|  ..|.:|.:::.|
Frog   562 YCRFSSKSDVWSFGVLMWEVFTLGRMPYDRFTNNEIVEQITRGVRLYRPQN--ATDRVYSIMVSC 624

  Fly   520 WDAVPEKRPTFEFLNH 535
            |....:.||||..|::
Frog   625 WAEKADDRPTFRILHN 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	14/50 (28%)
		SH2_Src_family	158..259	CDD:199827	32/100 (32%)
		STYKc	285..537	CDD:214568	114/251 (45%)
		PTKc_Src_like	289..538	CDD:270630	113/247 (46%)
btk	NP_001123732.1	PH_Btk	8..167	CDD:269944	9/33 (27%)
		SH3_BTK	209..264	CDD:212839	16/55 (29%)
		SH2_Tec_Btk	267..370	CDD:198260	33/106 (31%)
		PKc_like	388..638	CDD:419665	114/252 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910