Protein Alignment Atpalpha and ATP2C2

DIOPT Version :9

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_001273456.2
• Gene: ATP2C2 / 9914
• HGNCID: 29103
• Length: 975
• Species: Homo sapiens
• Alignment Length: 1063
• Identity: 313/1063 - (29%)
• Similarity: 483/1063 - (45%)
• Gaps: 204/1063 - (19%)

  Fly    33 QYKSRRK--MPAKVNKKENLDDLKQELDI------DFHKISPEELYQRFQTHPENGLSHAKAKEN 89
            ||::..|  ..|.::::..|..:::|..:      :..|...|:|.:.|......|||.....:.
Human    21 QYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQR 85

  Fly    90 LERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSE-EPADDNLYLGIV 153
            ....|.|........|.|.|:. :.|....:||.:|:.|      :...|.| |.|     :.|.
Human    86 RLAHGWNEFVADNSEPVWKKYL-DQFKNPLILLLLGSAL------VSVLTKEYEDA-----VSIA 138

  Fly   154 LSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIP 218
            .:.:|:||  .::.||.:|.|.:|....:||.....:|||:...|.|.:||.||||.:..|||||
Human   139 TAVLVVVT--VAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIP 201

  Fly   219 ADIRIIEARNFKVDNSSLTGESEPQSR-GAEFTHENPLET-KNLAFFSTNAVEGTAKGVVISCGD 281
            ||||:.|..:..||.||.|||:||.|: .:..|....|.| .|:.|..|....|..:||||..|:
Human   202 ADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGE 266

  Fly   282 HTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDA----VIFL 342
            .:..|.:..:....:|.:||:.|.:......:|   :|   :|.:|..|:...|...    .:|.
Human   267 SSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLT---LF---SFGIIGLIMLIGWSQGKQLLSMFT 325

  Fly   343 IGI--IVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMT 405
            ||:  .||.:||||...|.|.|.|...|||.|..:||.|..|||||..|.:|||||||||.|.||
Human   326 IGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMT 390

  Fly   406 VAHMWFDNQIIEAD-TTEDQSGVQYDRTS-----PGFKALSRIATLCNRAEFKGG--QDGVPILK 462
            |      .|::.:| ...:.|||.||...     |..:.:...:.:......:.|  .:...|.|
Human   391 V------TQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRK 449

  Fly   463 KEVSGDASEAALLK-CMELALGDVMN--IRKRNKKIAEVPFNSTNKY---QVSIHETEDTNDPRY 521
            ..|.|..:|.||:. .|::.|.|:.|  |||:     |:||:|..|:   :.|: :|||..|
Human   450 NAVMGQPTEGALMALAMKMDLSDIKNSYIRKK-----EIPFSSEQKWMAVKCSL-KTEDQED--- 505

  Fly   522 LLVMKGAPERILERCSTIFING----------KEKVLDEEMKEAFNNAYMELGGLGERVLGFCDF 576
            :..||||.|.::..| |::.||          :...|.||.:         :|.||.|||....
Human   506 IYFMKGALEEVIRYC-TMYNNGGIPLPLTPQQRSFCLQEEKR---------MGSLGLRVLALAS- 559

  Fly   577 MLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPIT 641
                              ...:..|.|:||:.:|||||..|.:||.....:|:.|.|:|||...|
Human   560 ------------------GPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALET 606

  Fly   642 AKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEI 706
            |.||.:::|:.:                        .|...:.|.|:..|...:|.:  |.....
Human   607 ALAIGRNIGLCN------------------------GKLQAMSGEEVDSVEKGELAD--RVGKVS 645

  Fly   707 VFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDD 771
            ||.||||:.||.|::..|..|||||:|||||||:.|||.||||:|||..|:||||:||:|||:||
Human   646 VFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDD 710

  Fly   772 NFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVP 836
            :|::|:..||||:.||.|:|..:.:.|:::|..:|......:.::|.||..:.||.|::..|..|
Human   711 DFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPP 775

  Fly   837 A-----------------------------ISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAY 872
            |                             ..|..|..:.|..::|||. ..|.:::..||
Human   776 AQRSSQKTEVCCTAVRLGVEGRGESTWAGRAGLGVEPVDKDAFRQPPRS-VRDTILSRALI---- 835

  Fly   873 GQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCH 937
              :.::.:||      :|::...|:..|     :|.:.:|....|            .|:.:||.
Human   836 --LKILMSAA------IIISGTLFIFWK-----EMPEDRASTPRT------------TTMTFTCF 875

  Fly   938 TAFFISIVVVQWADL---IICKTRRNSIFQQG-MRNWALNFGLVFETVLAAFLSYCPGMEKGLRM 998
            ..|          ||   :.|:::...||:.| :||....:.::...:....:.|.|.:::..:.
Human   876 VFF----------DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQT 930

  Fly   999 YPLKLVWWFPAIPFALAIFIYDE 1021
            ..|..:........|.::||..|
Human   931 ENLGALDLLFLTGLASSVFILSE 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	309/1049 (29%)
		Cation_ATPase_N	58..132	CDD:214842	17/79 (22%)
		E1-E2_ATPase	152..383	CDD:278548	85/238 (36%)
		Cation_ATPase	445..539	CDD:289987	31/101 (31%)
		COG4087	<695..770	CDD:226572	44/74 (59%)
		Cation_ATPase_C	817..1025	CDD:279079	45/238 (19%)
ATP2C2	NP_001273456.2	ATPase-IIA2_Ca	55..960	CDD:130585	307/1029 (30%)
		Cation_ATPase_N	63..125	CDD:279080	16/68 (24%)
		E1-E2_ATPase	149..368	CDD:278548	81/224 (36%)
		Cation_ATPase	441..523	CDD:289987	31/91 (34%)
		COG4087	<625..709	CDD:226572	47/85 (55%)
		Cation_ATPase_C	756..957	CDD:279079	45/238 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920