DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and PMR1

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_011348.1	Gene:	PMR1 / 852709	SGDID:	S000003135	Length:	950	Species:	Saccharomyces cerevisiae

Alignment Length:	1075	Identity:	326/1075 - (30%)
Similarity:	520/1075 - (48%)	Gaps:	197/1075 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DDDNRTADGQYKSRRKMPAKVNKKENLDDLKQEL-----DIDFHKISPEELYQRFQTHPENGL-S 82
            :|.||                 ::|.||...:.|     .:::..:|.:|..::..|....|| |
Yeast    13 EDSNR-----------------EREILDATAEALSKPSPSLEYCTLSVDEALEKLDTDKNGGLRS 60

  Fly    83 HAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEEPADDN 147
            ..:|.......|||.:|.......:.||..|......:||.||:.:.                 :
Yeast    61 SNEANNRRSLYGPNEITVEDDESLFKKFLSNFIEDRMILLLIGSAVV-----------------S 108

  Fly   148 LYLGIVLSAVVIVTGIF-----SYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGD 207
            |::|.:..||.|...||     .:.||.:|.|.:|:...:||....::|.|::..:.|..||.||
Yeast   109 LFMGNIDDAVSITLAIFIVVTVGFVQEYRSEKSLEALNKLVPAECHLMRCGQESHVLASTLVPGD 173

  Fly   208 VVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHEN----------PLETKN-LA 261
            :|..:.|||||||||||||.:..:|.|:||||:||..:.::...::          |:..:: :|
Yeast   174 LVHFRIGDRIPADIRIIEAIDLSIDESNLTGENEPVHKTSQTIEKSSFNDQPNSIVPISERSCIA 238

  Fly   262 FFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETP-------IAKEIHHFIHLITGVAVF 319
            :..|...||..||:|:..|.:|..|.:..:.:.::..:||       :.|::.....::.|:...
Yeast   239 YMGTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDKLGKDLSLVSFIVIGMICL 303

  Fly   320 LGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVET 384
            :|:       |.|..||:.....:.:.||.:||||...|||.|.|...|||.:..:|:.|.:|||
Yeast   304 VGI-------IQGRSWLEMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMAKRKAIVRRLPSVET 361

  Fly   385 LGSTSTICSDKTGTLTQNRMTVAHMW-FDN-----QIIEAD---TTEDQSGVQYDRTSPGFKALS 440
            |||.:.||||||||||.|.|||:.:| .|:     .::..|   .|::.:|...:..:...:...
Yeast   362 LGSVNVICSDKTGTLTSNHMTVSKLWCLDSMSNKLNVLSLDKNKKTKNSNGNLKNYLTEDVRETL 426

  Fly   441 RIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNK 505
            .|..|||.|.|  .|:....|     |:.::.|||:  :||..::.:||...:|:.|:||||..|
Yeast   427 TIGNLCNNASF--SQEHAIFL-----GNPTDVALLE--QLANFEMPDIRNTVQKVQELPFNSKRK 482

  Fly   506 YQVSIHETEDTN--DPRYLLVMKGAPERILERCSTIFINGKEK---VLDEEMKEAFNNAYMELGG 565
                :..|:..|  |.:..:.:|||.||||| .||.::..|.|   .|.|..|...|.....:..
Yeast   483 ----LMATKILNPVDNKCTVYVKGAFERILE-YSTSYLKSKGKKTEKLTEAQKATINECANSMAS 542

  Fly   566 LGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIK 630
            .|.||.||....|.....|     .|:|:   |.:|.|.||:.|.||||..|..|:.:....|:.
Yeast   543 EGLRVFGFAKLTLSDSSTP-----LTEDL---IKDLTFTGLIGMNDPPRPNVKFAIEQLLQGGVH 599

  Fly   631 VIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQ 695
            :||:|||...||..|||.:|                 |||  ::|   |.:|:.|.:|.::|.||
Yeast   600 IIMITGDSENTAVNIAKQIG-----------------IPV--IDP---KLSVLSGDKLDEMSDDQ 642

  Fly   696 LDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVS 760
            |..::. |..| |||.:|:.||.||...::.|.:||:|||||||:||||.:||||:||..|:||:
Yeast   643 LANVID-HVNI-FARATPEHKLNIVRALRKRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVA 705

  Fly   761 KQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTI 825
            |:|:||:|.||:|::|:|.:|||:.||:|::..:.:.|::::..:|.........:|.||..:.|
Yeast   706 KEASDMVLTDDDFSTILTAIEEGKGIFNNIQNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQI 770

  Fly   826 LCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKL----VNSRLISMAYGQI-GMIQAAAGFF 885
            |.|::..|..||.||..|..:.::||:|||.. .||:    |..||::.|...| |.:      :
Yeast   771 LWINILMDGPPAQSLGVEPVDHEVMKKPPRKR-TDKILTHDVMKRLLTTAACIIVGTV------Y 828

  Fly   886 VYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWA 950
            ::...|||:|                           :.|.|| .|:.:||...|       ...
Yeast   829 IFVKEMAEDG---------------------------KVTARD-TTMTFTCFVFF-------DMF 858

  Fly   951 DLIICKTRRNSIFQQG-----MRNWALNFGLVFETVLAAFLSYCPGMEK----GLRMYPLKLVWW 1006
            :.:.|:....|||:.|     |.|:|:...|:.: :.|.::.:...:.|    |:....|.|:
Yeast   859 NALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQ-MCAIYIPFFQSIFKTEKLGISDILLLLL-- 920

  Fly  1007 FPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
                 .:.::||.||.|:.:.|:...   |..||:
Yeast   921 -----ISSSVFIVDELRKLWTRKKNE---EDSTYF 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	322/1052 (31%)
		Cation_ATPase_N	58..132	CDD:214842	18/74 (24%)
		E1-E2_ATPase	152..383	CDD:278548	77/253 (30%)
		Cation_ATPase	445..539	CDD:289987	34/95 (36%)
		COG4087	<695..770	CDD:226572	40/74 (54%)
		Cation_ATPase_C	817..1025	CDD:279079	55/221 (25%)
PMR1	NP_011348.1	ATPase-IIA2_Ca	35..940	CDD:130585	316/1024 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920