Protein Alignment Atpalpha and ATP13A4

DIOPT Version :9

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_115655.2
• Gene: ATP13A4 / 84239
• HGNCID: 25422
• Length: 1196
• Species: Homo sapiens
• Alignment Length: 992
• Identity: 215/992 - (21%)
• Similarity: 379/992 - (38%)
• Gaps: 258/992 - (26%)

  Fly    23 TDDDNRTADGQY---KSRRKMPAKVN--KKENLDDLKQELDIDFHKI-SPEELYQRFQTHPENGL 81
            |.|.....|.:|   ::.||...||.  |.:.:..:...|:..|.|| |.|:.....:.|.:.|.
Human   104 TPDHPLMTDEEYIINRAIRKPDLKVRCIKVQKIRYVWNYLEGQFQKIGSLEDWLSSAKIHQKFGS 168

  Fly    82 SHAKAKENLER--DGPNALTPPKQTPEWVKFCKN------LFGGFAMLLWIGAILCFVAYSIQAS 138
            ...:.::.:.|  .|||.: ..:.||.|....|.      :|..|::.||........|::|
Human   169 GLTREEQEIRRLICGPNTI-DVEVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAI--- 229

  Fly   139 TSEEPADDNLYLGIVLSAVVIVTGIFSYYQES-KSSKIMESFKNMVPQFATVIREGEKL---TLR 199
                         |::|.:.|...::...::| |...::||..::     ||...|.|.   .|.
Human   230 -------------IIMSIISISLTVYDLREQSVKLHHLVESHNSI-----TVSVCGRKAGVQELE 276

  Fly   200 AEDLVLGDVVEVKFGDRI--PADIRIIEARNFKVDNSSLTGESEPQSRG--AEFTHENPLET--- 257
            :..||.||:: :..|:::  |.|..:||. :..||...|||||.|.::.  .:.....|.:|
Human   277 SRVLVPGDLL-ILTGNKVLMPCDAVLIEG-SCVVDEGMLTGESIPVTKTPLPKMDSSVPWKTQSE 339

  Fly   258 ----KNLAFFSTNAVE------GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHL 312
                :::.|..|..::      ||.:.||:..|.:|..|.:.............:.::...|:..
Human   340 ADYKRHVLFCGTEVIQAKAACSGTVRAVVLQTGFNTAKGDLVRSILYPKPVNFQLYRDAIRFLLC 404

  Fly   313 ITGVAVFLGVTFFVIAFIL-GYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLV 376
            :.|.|. :|:.:.:..::| |....:.|...:.:|...||..|.|.:|..:....:|:..:....
Human   405 LVGTAT-IGMIYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAALTTGIIYAQRRLKKRGIFC 468

  Fly   377 KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSR 441
            .:.:.:...|..:.:|.|||||||::.:   .:|              ..|..||.  ||:.:.
Human   469 ISPQRINVCGQLNLVCFDKTGTLTRDGL---DLW--------------GVVSCDRN--GFQEVH- 513

  Fly   442 IATLCNRAEFKGGQDGVP---------------ILKKEVSGDASEAALLKC--MELAL-GDVMNI 488
                    .|..|| .:|               :|...:.||..:..:.:.  .|:|. ||..:|
Human   514 --------SFASGQ-ALPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFSGDDFHI 569

  Fly   489 R---------KRNKKIAEV-----------PFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERIL 533
            :         |..:..::|           ||:|..:....|  .::....| |..|||||||:.
Human   570 KGVPAHAMVVKPCRTASQVPVEGIAILHQFPFSSALQRMTVI--VQEMGGDR-LAFMKGAPERVA 631

  Fly   534 ERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPI 598
            ..|.           .|.:..:|.:........|.||:......|.:|.:.......|.:
Human   632 SFCQ-----------PETVPTSFVSELQIYTTQGFRVIALAYKKLENDHHATTLTRETVE----- 680

  Fly   599 DNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIIS--------EG 655
            .:|.|:||:.:.:..:......:.:..||.|:.:|:|||:..||..:|:..|::|        |.
Human   681 SDLIFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVARKSGMVSESQKVILIEA 745

  Fly   656 NETVEDIAQRLNIPVSEVNPREAKAAVVHGAE-----LRDVSSDQ-------------------- 695
            |||....:..::..:.     |.|..:::|.:     :||..||:
Human   746 NETTGSSSASISWTLV-----EEKKHIMYGNQDNYINIRDEVSDKGREGSYHFALTGKSFHVISQ 805

  Fly   696 -----LDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIA 755
                 |.:||...|  :|||.||.||..:||..|::...|.:.|||.||..|||.|.:|:::
Human   806 HFSSLLPKILINGT--IFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGISL--- 865

  Fly   756 GSDVSKQAADMI---------------LLDDNFASIVT--------------------------- 778
                |:|.|.:.               |:.:..|::||
Human   866 ----SEQEASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMIQYVGVLLLYWETN 926

  Fly   779 GVEEGRLIFDNLKKSIAYTLTSNI----PEISPFL-AFILCDIPLPLGTV-TILCIDLGTDMVPA 837
            .:...:.:|.:|..:....:|.|:    |::.||. |..|...||.|..: .||
Human   927 SLSNYQFLFQDLAITTLIGVTMNLNGAYPKLVPFRPAGRLISPPLLLSVIFNIL----------- 980

  Fly   838 ISLAYEHAEADIMKRPP 854
            :|||...|...:::|.|
Human   981 LSLAMHIAGFILVQRQP 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	207/967 (21%)
		Cation_ATPase_N	58..132	CDD:214842	19/82 (23%)
		E1-E2_ATPase	152..383	CDD:278548	54/252 (21%)
		Cation_ATPase	445..539	CDD:289987	28/131 (21%)
		COG4087	<695..770	CDD:226572	29/114 (25%)
		Cation_ATPase_C	817..1025	CDD:279079	11/39 (28%)
ATP13A4	NP_115655.2	P5-ATPase	16..136	CDD:289194	9/31 (29%)
		P-ATPase-V	17..1114	CDD:273738	215/992 (22%)
		Cation_ATPase_N	157..217	CDD:279080	12/60 (20%)
		E1-E2_ATPase	268..471	CDD:278548	44/205 (21%)
		Cation_ATPase	<595..634	CDD:289987	13/41 (32%)
		COG4087	<820..>869	CDD:226572	22/55 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910