DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and HA3

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001190559.1	Gene:	HA3 / 835841	AraportID:	AT5G57350	Length:	949	Species:	Arabidopsis thaliana

Alignment Length:	1026	Identity:	248/1026 - (24%)
Similarity:	428/1026 - (41%)	Gaps:	205/1026 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNL 114
            |:|:..| ::|..||..||::|:.:...| |||.|:.:..|:..|||.|...|::    |..|
plant     5 LEDIVNE-NVDLEKIPIEEVFQQLKCSRE-GLSGAEGENRLQIFGPNKLEEKKES----KLLK-- 61

  Fly   115 FGGFAM--LLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIME 177
            |.||..  |.|:......:|.:: |:...:|.|...::|||  .::::....|:.:|:.:.....
plant    62 FLGFMWNPLSWVMEAAAIMAIAL-ANGGGKPPDWQDFVGIV--CLLVINSTISFVEENNAGNAAA 123

  Fly   178 SFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEP 242
            :....:.....|:|:|:.....|..||.||:|.:|.||.||||.|::|....|||.|:|||||.|
plant   124 ALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLP 188

  Fly   243 QSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIH 307
            .::|       |.|.   .|..:...:|..:.|||:.|.||..|:.|.|...        ..::.
plant   189 ATKG-------PGEE---VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDS--------TNQVG 235

  Fly   308 HFIHLIT--------GVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTL 364
            ||..::|        .:||.:.:...|:..|...|:.|.:..|:.:::..:|..:...::|.:.:
plant   236 HFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAI 300

  Fly   365 TAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQY 429
            .:.:::.:..:.|.:.|:|.:.....:|||||||||.|:::|     |..:||...    .||:.
plant   301 GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSV-----DKNLIEVYC----KGVEK 356

  Fly   430 DRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKK 494
            |.       :...|...:|.|               :.||.:||::.    .|.|....|...::
plant   357 DE-------VLLFAARASRVE---------------NQDAIDAAMVG----MLADPKEARAGIRE 395

  Fly   495 IAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNA 559
            |..:|||..:|.........:.|..|   |.|||||:||:.|:.          ..::::..::.
plant   396 IHFLPFNPVDKRTALTFIDSNGNWHR---VSKGAPEQILDLCNA----------RADLRKRVHST 447

  Fly   560 YMELGGLGERVLGFCDFMLP-SDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPDAVAK 623
            ..:....|.|.|......:| ..|..:|..:            .|||::.:.||||....:.:.:
plant   448 IDKYAERGLRSLAVSRQTVPEKTKESSGSPW------------EFVGVLPLFDPPRHDSAETIRR 500

  Fly   624 CRSAGIKVIMVTGDHPITAKAIAKSVGIISE--------GNETVEDIAQRLNIPVSEVNPREAKA 680
            ....|:.|.|:|||....||...:.:|:.|.        |....|.:|   :|||.::
plant   501 ALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSSLLGKHKDEAMA---HIPVEDL------- 555

  Fly   681 AVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKK 745
                 .|..|                .||...|:.|..||:..|....|..:|||||||:|||||
plant   556 -----IEKAD----------------GFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKK 599

  Fly   746 ADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLA 810
            ||||:|:..| :|.::.|:|::|.:...:.|::.|...|.||..:|....|.::..|..:..|:.
plant   600 ADIGIAVADA-TDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFML 663

  Fly   811 FILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMK---RPPRDPFNDKLVNSRLISMAY 872
            ..|           |...|....||..|::..:.....|.|   :|...|.:.||.......:..
plant   664 IAL-----------IWKFDFSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVL 717

  Fly   873 GQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCH 937
            |....|.....|:..:                           .||.:.:.:..||.:..|:...
plant   718 GGYMAIMTVVFFWAAY---------------------------KTDFFPRTFHVRDLRGSEHEMM 755

  Fly   938 TAFFISIVVVQWADLIICKTRRNSIFQQG-----MRNWALNFGLVFETVLAAFLSYCPGMEKGLR 997
            :|.::.:.:|..|.:.:.::|..|..::.     :..|...   :..|.:|.:.::.....||:.
plant   756 SALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQ---LIATAIAVYGNWEFARIKGIG 817

  Fly   998 ------MYPLKLVWWFP------AIPFALA----IFIYDETRRFYLRRNPG 1032
                  ::...:|::||      ||.:.||    ..|.|....|..::|.|
plant   818 WGWAGVIWLYSIVFYFPLDIMKFAIRYILAGTAWKNIIDNRTAFTTKQNYG 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	248/1026 (24%)
		Cation_ATPase_N	58..132	CDD:214842	24/75 (32%)
		E1-E2_ATPase	152..383	CDD:278548	60/238 (25%)
		Cation_ATPase	445..539	CDD:289987	25/93 (27%)
		COG4087	<695..770	CDD:226572	30/74 (41%)
		Cation_ATPase_C	817..1025	CDD:279079	38/231 (16%)
HA3	NP_001190559.1	ATPase-IIIA_H	33..805	CDD:273731	224/931 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910