DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and HA4

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001325714.1	Gene:	HA4 / 823950	AraportID:	AT3G47950	Length:	960	Species:	Arabidopsis thaliana

Alignment Length:	1032	Identity:	249/1032 - (24%)
Similarity:	438/1032 - (42%)	Gaps:	201/1032 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 NKKENLDDLKQELDIDFHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVK 109
            :.:|.|:.:.:|. :|...:..||:::..:...| ||:...|.|.|...|.|.|...|::    |
plant     7 DNREVLEAVLKEA-VDLENVPIEEVFENLRCSKE-GLTTQAADERLALFGHNKLEEKKES----K 65

  Fly   110 FCKNLFGGFAM--LLWIGAILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKS 172
            |.|  |.||..  |.|:......:|.:: |:...:|.|...::||:  .::::....|:.:|:.:
plant    66 FLK--FLGFMWNPLSWVMEAAAIMAIAL-ANGGGKPPDWQDFVGII--TLLVINSTISFIEENNA 125

  Fly   173 SKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLT 237
            .....:....:...|.|:|:|......|..||.||::.:|.||.:|||.|::|....|:|.|:||
plant   126 GNAAAALMARLAPKAKVLRDGRWGEQDAAILVPGDIISIKLGDIVPADARLLEGDPLKIDQSALT 190

  Fly   238 GESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTAKGVVISCGDHTVMGRIAGLASGLDTGETPI 302
            |||.|.::          .:.:..:..:...:|..:.|||:.|.||..|:.|.|   :||
plant   191 GESLPVTK----------SSGDGVYSGSTCKQGEIEAVVIATGVHTFFGKAAHL---VDT----- 237

  Fly   303 AKEIHHFIHLITGVAVF------LGVTFFVIAFILGYH--WLDAVIFLIGIIVANVPEGLLATVT 359
            ..:|.||..::|.:..|      :|:...::......|  :...:..|:.:::..:|..:...::
plant   238 TNQIGHFQQVLTAIGNFCICSIAVGMLIEIVVMYPIQHRAYRPGIDNLLVLLIGGIPIAMPTVLS 302

  Fly   360 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQ 424
            |.:.:.:.|::.:..:.|.:.|:|.:.....:|||||||||.|::||     |..:||.    ..
plant   303 VTMAIGSHRLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLTV-----DKNLIEV----FM 358

  Fly   425 SGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIR 489
            .||..|       .:..:|...:|.|               :.||.:||::.    .|.|..:.|
plant   359 KGVDAD-------TVVLMAARASRLE---------------NQDAIDAAIVG----MLADPKDAR 397

  Fly   490 KRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERILERCSTIFINGKEKVLDEEMKE 554
            ...:::..:|||.|:|.....:...:.|..|   |.|||||:||.     ..:.|.::  |....
plant   398 AGIQEVHFLPFNPTDKRTALTYIDNEGNTHR---VSKGAPEQILN-----LAHNKSEI--ERRVH 452

  Fly   555 AFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPIDNLRFVGLMSMIDPPRAAVPD 619
            |..:.:.| .||....:.:.|       .|.|.|   |....|   .:|||||.:.||||....:
plant   453 AVIDKFAE-RGLRSLAVAYQD-------VPEGRK---DSAGGP---WQFVGLMPLFDPPRHDSAE 503

  Fly   620 AVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNI-PVSEV---NPREAKA 680
            .:.:..:.|:.|.|:|||.             ::.|.||...:....|: |.|.:   |..|:..
plant   504 TIRRALNLGVSVKMITGDQ-------------LAIGKETGRRLGMGTNMYPSSALLGQNKDESIV 555

  Fly   681 AVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKK 745
            |:            .:||::.....  ||...|:.|..||:..|....|..:|||||||:|||||
plant   556 AL------------PVDELIEKADG--FAGVFPEHKYEIVKRLQARKHICGMTGDGVNDAPALKK 606

  Fly   746 ADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLA 810
            ||||:|:..| :|.::.|:|::|.:...:.|::.|...|.||..:|....|.::..|..:..|:.
plant   607 ADIGIAVADA-TDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVLGFML 670

  Fly   811 FILC---DIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAY 872
            ..|.   |.| |...:.|..::.||.|.         ...|.:|..|. |.:.||.......:.:
plant   671 LALIWQFDFP-PFMVLIIAILNDGTIMT---------ISKDRVKPSPL-PDSWKLSEIFATGVVF 724

  Fly   873 GQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCH 937
            |....:...    ::|.:..:..|.| :.||:                         .|||.|.|
plant   725 GSYMAMMTV----IFFWVSYKTDFFP-RTFGV-------------------------ATLEKTAH 759

  Fly   938 -------TAFFISIVVVQWADLIICKTR------RNSIFQQGMRNWALNFGLVFETVLAAFLSYC 989
                   :|.::.:.::..|.:.:.::|      |..||..    .|.....:..|::|.:.::.
plant   760 DDFRKLASAIYLQVSIISQALIFVTRSRSWSFVERPGIFLM----IAFILAQLVATLIAVYANWS 820

  Fly   990 PGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGG--W---LEQETYY 1041
            ....:|:......::|.:..|.:....||     :|::|....|  |   :||...:
plant   821 FAAIEGIGWGWAGVIWLYNIIFYIPLDFI-----KFFIRYALSGRAWDLVIEQRVAF 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	249/1030 (24%)
		Cation_ATPase_N	58..132	CDD:214842	21/75 (28%)
		E1-E2_ATPase	152..383	CDD:278548	54/238 (23%)
		Cation_ATPase	445..539	CDD:289987	24/93 (26%)
		COG4087	<695..770	CDD:226572	32/74 (43%)
		Cation_ATPase_C	817..1025	CDD:279079	37/220 (17%)
HA4	NP_001325714.1	ATPase-IIIA_H	40..816	CDD:273731	231/934 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910